Sarah Courtois1, Lucie Bénéjat1,2, Julien Izotte3, Francis Mégraud1,2, Christine Varon1, Philippe Lehours1,2, Emilie Bessède1,2. 1. INSERM, University of Bordeaux, UMR 1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France. 2. French National Reference Center for Campylobacters & Helicobacters in Bordeaux (CNRCH), University Hospital of Bordeaux, France. 3. Animal facilities A2, University of Bordeaux, France.
Abstract
AIM: Helicobacter pylori infection is a worldwide infection, its eradication rates with conventional therapies have fallen to unacceptable levels. In this context we were interested in metformin, to determine its effect on H. pylori growth. MATERIALS & METHODS: Antimicrobial susceptibility tests and survival curves were performed in vitro and a H. pylori-infected mice model was used to determine metformin effect in vivo. RESULTS: Helicobacter pylori survival and growth were decreased in presence of metformin. Furthermore, metformin-treated mice had significantly less bacteria in their stomach than the untreated mice. CONCLUSION: Our work is the first to demonstrate a direct antimicrobial effect of metformin on H. pylori, indicating that this molecule has not yet revealed its full potential.
AIM: Helicobacter pyloriinfection is a worldwide infection, its eradication rates with conventional therapies have fallen to unacceptable levels. In this context we were interested in metformin, to determine its effect on H. pylori growth. MATERIALS & METHODS: Antimicrobial susceptibility tests and survival curves were performed in vitro and a H. pylori-infected mice model was used to determine metformin effect in vivo. RESULTS:Helicobacter pylori survival and growth were decreased in presence of metformin. Furthermore, metformin-treated mice had significantly less bacteria in their stomach than the untreated mice. CONCLUSION: Our work is the first to demonstrate a direct antimicrobial effect of metformin on H. pylori, indicating that this molecule has not yet revealed its full potential.