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Literature DB >> 30421488

Zinc(II)-Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy.

Chengchao Chu¹, En Ren¹, Yunming Zhang¹, Jingwen Yu², Huirong Lin¹, Xin Pang¹, Yang Zhang¹, Heng Liu¹, Zainen Qin¹, Yi Cheng¹, Xiaoyong Wang¹, Wei Li², Xiangjian Kong³, Xiaoyuan Chen⁴, Gang Liu^1,3.

Abstract

We report the rational design of coordination-driven self-assembly metal-organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination-based nano-formulations capable of loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging-guided combination photo/gene therapy strategy. We showed the enhanced theranostic capability of zinc(II)-dipicolylamine-assisted assembly of ICG, as well as simultaneous targeted gene delivery in an experimental mouse model of cancer. Such a co-assembly strategy provides a facile way to achieve combined therapeutic functions for personalized nanomedicine.

Entities: Chemical Disease Species

Keywords: ZnII-dipicolylamine; gene therapy; indocyanine green; metal-organic nanostructures; phototherapy

Year: 2018 PMID： 30421488 DOI： 10.1002/anie.201812482

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

19 in total

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Zinc(II)-Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy.

Review 1. Current Advances in Black Phosphorus-Based Drug Delivery Systems for Cancer Therapy.

2. Transforming a clinical fluorescent dye to sense and treat iron overload disorders: a new reverse translational approach in precision medicine.

Review 3. Applications of Metal-Organic Frameworks as Drug Delivery Systems.

4. A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization.

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Review 6. Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment.

Review 7. Host-Guest Chemistry in Supramolecular Theranostics.

8. Bioinspired Membrane-Coated Nanoplatform for Targeted Tumor Immunotherapy.

Review 9. The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials.

Review 10. Metal-Coordinated Supramolecular Self-Assemblies for Cancer Theranostics.