Ann Olsson1, Liacine Bouaoun2, Anssi Auvinen3, Maria Feychting4, Christoffer Johansen5,6, Tiit Mathiesen7,8, Beatrice Melin9, Anna Lahkola10, Suvi Larjavaara11, Anne-Sophie Villegier12, Graham Byrnes2, Isabelle Deltour2, Joachim Schüz2. 1. Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France. olssona@iarc.fr. 2. Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon CEDEX 08, France. 3. Faculty of Social Sciences, Health Sciences, University of Tampere, Tampere, Finland. 4. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. 5. Oncology Clinic, 5073 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 6. Survivorship Unit, The Danish Cancer Society Research Center, Copenhagen, Denmark. 7. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. 8. University of Copenhagen, Rigshospitalet, Copenhagen, Denmark. 9. Department of Radiation Sciences, Oncology, Umeå University Hospital, Umeå, Sweden. 10. Radiation and Nuclear Safety Authority (STUK), Helsinki, Finland. 11. Helsinki University Hospital, Helsinki, Finland. 12. INERIS, Toxicologie Expérimentale, Verneuil-en-Halatte, France.
Abstract
PURPOSE: Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastoma patients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among glioma patients. METHODS: Glioma cases (n = 806) previously enrolled in a collaborative population-based case-control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status. RESULTS: No indication of reduced survival among glioblastoma patients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas. CONCLUSIONS: We found no evidence of reduced survival among glioma patients in relation to previous mobile phone use.
PURPOSE:Gliomas are the most common cancer of the brain, with a poor prognosis in particular for glioblastoma. In 2014, a study suggested reduced survival in relation to latency of mobile phone use among glioblastomapatients. A joint epidemiological/experimental project to study effects of RF-EMF on tumor development and progression was established. The current analysis relates to the epidemiological part and addresses whether pre-diagnostic mobile phone use was associated with survival among gliomapatients. METHODS:Glioma cases (n = 806) previously enrolled in a collaborative population-based case-control study in Denmark, Finland and Sweden were followed up for survival. Vital status, date of death, date of emigration, or date last known to be alive was obtained based on registry linkages with a unique personal ID in each country. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) stratified by country. Covariates investigated were sex, age, education, histology, treatment, anatomic location and marital status. RESULTS: No indication of reduced survival among glioblastomapatients was observed for various measures of mobile phone use (ever regular use, time since start of regular use, cumulative call time overall or in the last 12 months) relative to no or non-regular use. All significant associations suggested better survival for mobile phone users. Results were similar for high-grade and low-grade gliomas. CONCLUSIONS: We found no evidence of reduced survival among gliomapatients in relation to previous mobile phone use.
Entities:
Keywords:
Case–control studies; Glioma; Mobile phones; Radiofrequency electromagnetic fields; Survival
Authors: Isabelle Deltour; Aslak Harbo Poulsen; Christoffer Johansen; Maria Feychting; Tom Børge Johannesen; Anssi Auvinen; Joachim Schüz Journal: Environ Int Date: 2022-08-24 Impact factor: 13.352