| Literature DB >> 30420754 |
Yinghong Wang1, Diana H Wiesnoski2, Beth A Helmink3, Vancheswaran Gopalakrishnan3, Kati Choi4, Hebert L DuPont5,6, Zhi-Dong Jiang5, Hamzah Abu-Sbeih7, Christopher A Sanchez2, Chia-Chi Chang2, Edwin R Parra8, Alejandro Francisco-Cruz8, Gottumukkala S Raju7, John R Stroehlein7, Matthew T Campbell9, Jianjun Gao9, Sumit K Subudhi9, Dipen M Maru10, Jorge M Blando11, Alexander J Lazar2,10, James P Allison11, Padmanee Sharma9,11, Michael T Tetzlaff8,10, Jennifer A Wargo2,3, Robert R Jenq2,12.
Abstract
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.Entities:
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Year: 2018 PMID： 30420754 PMCID： PMC6322556 DOI： 10.1038/s41591-018-0238-9
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440