Literature DB >> 30420481

High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis.

Matthieu Grégoire1,2, Benjamin Gaborit3,4, Colin Deschanvres3, Raphaël Lecomte3, Guillaume Deslandes5, Éric Dailly5,6, Xavier Ambrosi7, Ronan Bellouard5,6, Nathalie Asseray3, Karim Lakhal7, David Boutoille3,4.   

Abstract

A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus (MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectively. Free concentrations in the cerebrospinal fluid were always above the MIC usually displayed by methicillin-susceptible Staphylococcus aureus (MSSA) isolates. These results support the use of high-dose cefazolin to achieve sufficient meningeal concentrations.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  cefazolin; cerebrospinal fluid; healthcare-associated infection; meningitis; pharmacokinetics

Mesh：

Substances：

Year:  2019        PMID： 30420481      PMCID： PMC6355608          DOI： 10.1128/AAC.01844-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections.

Authors:  Roland Nau; Fritz Sörgel; Helmut Eiffert
Journal:  Clin Microbiol Rev       Date:  2010-10       Impact factor: 26.132

2.  Prevention of external ventricular drain--related ventriculitis.

Authors:  A-M Korinek; M Reina; A L Boch; A O Rivera; D De Bels; L Puybasset
Journal:  Acta Neurochir (Wien)       Date:  2005-01       Impact factor: 2.216

3.  MIC-based dose adjustment: facts and fables.

Authors:  Johan W Mouton; Anouk E Muller; Rafael Canton; Christian G Giske; Gunnar Kahlmeter; John Turnidge
Journal:  J Antimicrob Chemother       Date:  2018-03-01       Impact factor: 5.790

Review 4.  Antibiotic Distribution into Cerebrospinal Fluid: Can Dosing Safely Account for Drug and Disease Factors in the Treatment of Ventriculostomy-Associated Infections?

Authors:  Nilesh Kumta; Jason A Roberts; Jeffrey Lipman; Menino Osbert Cotta
Journal:  Clin Pharmacokinet       Date:  2018-04       Impact factor: 6.447

5.  Influence of lipophilicity on the diffusion of cephalosporins into the cerebrospinal fluid.

Authors:  A Radouane; F Péhourcq; G Tramu; E E Creppy; B Bannwarth
Journal:  Fundam Clin Pharmacol       Date:  1996       Impact factor: 2.748

6.  Seizures associated with high cerebrospinal fluid concentrations of cefazolin.

Authors:  T P Bechtel; R L Slaughter; T D Moore
Journal:  Am J Hosp Pharm       Date:  1980-02

7.  Effect of multidose therapy on cerebrospinal fluid penetration of cefazolin.

Authors:  T D Moore; T P Bechtel; L W Ayers
Journal:  Am J Hosp Pharm       Date:  1981-10

8.  Inoculum effect of high concentrations of methicillin-susceptible Staphylococcus aureus on the efficacy of cefazolin and other beta-lactams.

Authors:  Masachika Saeki; Masaaki Shinagawa; Yuki Yakuwa; Shinya Nirasawa; Yuki Sato; Nozomi Yanagihara; Satoshi Takahashi
Journal:  J Infect Chemother       Date:  2017-12-01       Impact factor: 2.211

Review 9.  Nosocomial ventriculitis and meningitis in neurocritical care patients.

Authors:  R Beer; P Lackner; B Pfausler; E Schmutzhard
Journal:  J Neurol       Date:  2008-12-08       Impact factor: 4.849

10.  Cefazolin versus Nafcillin for Methicillin-Sensitive Staphylococcus aureus Bloodstream Infection in a California Tertiary Medical Center.

Authors:  S Pollett; S M Baxi; G W Rutherford; S B Doernberg; P Bacchetti; H F Chambers
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191
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  3 in total

1.  A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges.

Authors:  Nilesh Kumta; Jason A Roberts; Jeffrey Lipman; Wai Tat Wong; Gavin M Joynt; Menino Osbert Cotta
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

Review 2.  Current Perspectives on the Diagnosis and Management of Healthcare-Associated Ventriculitis and Meningitis.

Authors:  Marios Karvouniaris; Alexandros Brotis; Konstantinos Tsiakos; Eleni Palli; Despoina Koulenti
Journal:  Infect Drug Resist       Date:  2022-02-28       Impact factor: 4.003

3.  Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients.

Authors:  Alison R Novak; Martin Krsak; Tyree H Kiser; Robert T Neumann; Luis Cava Prado; Kyle C Molina; Scott W Mueller
Journal:  Open Forum Infect Dis       Date:  2021-12-25       Impact factor: 3.835
  3 in total

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