Marjorie L McCullough 1 , Rebecca A Hodge 2 , Caroline Y Um 2 , Susan M Gapstur 2 Show Affiliations »
Abstract
BACKGROUND: Acrylamide, an industrial chemical and probable human carcinogen, can be formed in primarily carbohydrate-containing foods during high-heat cooking or processing. Most epidemiologic studies show no associations of dietary acrylamide intake with most cancer outcomes, but limited prospective evidence suggests a positive association with renal cell carcinoma (RCC). METHODS: In 1999, 102,154 men and women from the Cancer Prevention Study-II Nutrition Cohort completed a questionnaire on diet, lifestyle, and cancer risk factors and were followed through June 30, 2013. Cox proportional hazards regression was used to estimate the HR and 95% confidence interval (CI) for the association between estimated dietary acrylamide intake and risk of RCC. RESULTS: After 1,137,441 person-years of follow-up, 412 cases of invasive RCC occurred. In multivariable-adjusted models, there was no association between acrylamide intake and risk of RCC (HR = 1.09; 95% CI, 0.82-1.43) for the highest versus lowest quartile of intake. Associations were not modified by sex or smoking history. CONCLUSIONS: We found no associations between dietary acrylamide exposure and risk of invasive RCC. IMPACT: The findings from this large, prospective analysis do not support a positive association between higher dietary acrylamide intake and RCC risk. ©2018 American Association for Cancer Research.
BACKGROUND: Acrylamide , an industrial chemical and probable human carcinogen, can be formed in primarily carbohydrate -containing foods during high-heat cooking or processing. Most epidemiologic studies show no associations of dietary acrylamide intake with most cancer outcomes, but limited prospective evidence suggests a positive association with renal cell carcinoma (RCC ). METHODS: In 1999, 102,154 men and women from the Cancer Prevention Study-II Nutrition Cohort completed a questionnaire on diet, lifestyle, and cancer risk factors and were followed through June 30, 2013. Cox proportional hazards regression was used to estimate the HR and 95% confidence interval (CI) for the association between estimated dietary acrylamide intake and risk of RCC . RESULTS: After 1,137,441 person -years of follow-up, 412 cases of invasive RCC occurred. In multivariable-adjusted models, there was no association between acrylamide intake and risk of RCC (HR = 1.09; 95% CI, 0.82-1.43) for the highest versus lowest quartile of intake. Associations were not modified by sex or smoking history. CONCLUSIONS: We found no associations between dietary acrylamide exposure and risk of invasive RCC . IMPACT: The findings from this large, prospective analysis do not support a positive association between higher dietary acrylamide intake and RCC risk. ©2018 American Association for Cancer Research.
Entities: Chemical
Disease
Species
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Year: 2018
PMID： 30420439 DOI： 10.1158/1055-9965.EPI-18-0909
Source DB: PubMed Journal: Cancer Epidemiol Biomarkers Prev ISSN： 1055-9965 Impact factor: 4.254