Literature DB >> 30420160

TRPM2 activation: Paradigm shifted?

Ralf Fliegert1, Hans T Hölzer1, Andreas H Guse2.   

Abstract

Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just reflects evolution of the channel?.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ADPR; Calcium; Ion channel structure; TRP channel

Mesh：

Substances：

Year:  2018        PMID： 30420160     DOI： 10.1016/j.ceca.2018.11.001

Source DB:  PubMed          Journal:  Cell Calcium        ISSN： 0143-4160            Impact factor:   6.817


  7 in total

Review 1.  Transient Receptor Potential Channels and Calcium Signaling.

Authors:  Laura Vangeel; Thomas Voets
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-06-03       Impact factor: 10.005

2.  Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX.

Authors:  I Cruz-Torres; D S Backos; P S Herson
Journal:  Mol Pharmacol       Date:  2019-11-26       Impact factor: 4.436

Review 3.  NAADP Receptors.

Authors:  Antony Galione
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-11-01       Impact factor: 10.005

4.  The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn2+ -binding domain essential for structural integrity and channel activity.

Authors:  Simon Sander; Jelena Pick; Ellen Gattkowski; Ralf Fliegert; Henning Tidow
Journal:  Protein Sci       Date:  2022-06       Impact factor: 6.993

5.  Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.

Authors:  Yihe Huang; Becca Roth; Wei Lü; Juan Du
Journal:  Elife       Date:  2019-09-12       Impact factor: 8.140

6.  CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.

Authors:  José-Manuel Cancela; Sabine de la Porte; Antoine de Zélicourt; Abdallah Fayssoil; Mbarka Dakouane-Giudicelli; Isley De Jesus; Ahmed Karoui; Faouzi Zarrouki; Florence Lefebvre; Arnaud Mansart; Jean-Marie Launay; Jerome Piquereau; Mariana G Tarragó; Marcel Bonay; Anne Forand; Sophie Moog; France Piétri-Rouxel; Elise Brisebard; Claudia C S Chini; Sonu Kashyap; Matthew J Fogarty; Gary C Sieck; Mathias Mericskay; Eduardo N Chini; Ana Maria Gomez
Journal:  EMBO Mol Med       Date:  2022-03-17       Impact factor: 14.260

7.  cADPR Does Not Activate TRPM2.

Authors:  Winnie Maria Riekehr; Simon Sander; Jelena Pick; Henning Tidow; Andreas Bauche; Andreas H Guse; Ralf Fliegert
Journal:  Int J Mol Sci       Date:  2022-03-15       Impact factor: 5.923
  7 in total

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