Mariam Hakobyan1, Koen P Dijkman2, Sabrina Laroche3, Gunnar Naulaers4, Monique Rijken5, Katerina Steiner6, Henrica L M van Straaten7, Renate M C Swarte8, Hendrik J Ter Horst9, Alexandra Zecic10, Inge A Zonnenberg11, Floris Groenendaal12. 1. Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands. 2. Department of Neonatology, Máxima Medical Centre, Veldhoven, The Netherlands. 3. Department of Neonatology, University Hospital, Antwerp, Belgium. 4. Department of Neonatology, University Hospital, Leuven, Belgium. 5. Department of Neonatology, Leiden University Medical Center, Leiden, The Netherlands. 6. Department of Neonatology, Radboud University Medical Center, Radboud Institute for Health Science, Amalia Children's Hospital, Nijmegen, The Netherlands. 7. Department of Neonatology, Isala Clinics, Zwolle, The Netherlands. 8. Department of Neonatology, Erasmus Medical Center Sophia, Rotterdam, The Netherlands. 9. Department of Neonatology, Beatrix Children's Hospital, University Medical Centre Groningen, Groningen, The Netherlands. 10. Department of Neonatology, University Hospital, Gent, Belgium. 11. Department of Neonatology, VU University Medical Center, Amsterdam, The Netherlands. 12. Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands, F.Groenendaal@umcutrecht.nl.
Abstract
BACKGROUND: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. OBJECTIVES: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. METHODS: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1-42.6 weeks and birth weight 2,280-5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. RESULTS: Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. CONCLUSION: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants.
BACKGROUND: Animal models suggest that neuroprotective effects of therapeutic hypothermia (TH) after perinatal asphyxia are reduced in infants with early-onset sepsis. OBJECTIVES: To assess the outcome of infants with perinatal asphyxia, neonatal encephalopathy, and TH in the presence of early-onset sepsis. METHODS: In a retrospective cohort of 1,084 infants with perinatal asphyxia and TH, the outcome of 42 infants (gestational age 36.1-42.6 weeks and birth weight 2,280-5,240 g) with proven sepsis (n = 14) and probable sepsis (n = 28) was analyzed. Death, cerebral palsy, or a delayed development at 2 years was considered an adverse outcome. RESULTS:Sepsis was caused mostly by group B streptococci (n = 17), other Gram-positive bacteria (n = 5), and Candida albicans (n = 1). Of the 42 infants, 9 (21.4%) died, and 5 (11.9%) showed impairments on follow-up. The outcome is comparable to the previously reported outcome of infants with TH without early-onset sepsis. CONCLUSION: A good outcome was reported in the majority of infants with perinatal asphyxia, TH, and early-onset sepsis. Cooling should not be withheld from these infants.
Authors: Jennifer B Brandt; Sabine Steiner; Gerald Schlager; Kambis Sadeghi; Regina Vargha; Johann Golej; Michael Hermon Journal: Acta Paediatr Date: 2020-08-12 Impact factor: 2.299
Authors: Maria E Bernis; Yvonne Schleehuber; Margit Zweyer; Elke Maes; Ursula Felderhoff-Müser; Daniel Picard; Hemmen Sabir Journal: Oxid Med Cell Longev Date: 2022-03-02 Impact factor: 6.543
Authors: Agata Tarkowska; Wanda Furmaga-Jabłońska; Jacek Bogucki; Janusz Kocki; Ryszard Pluta Journal: J Clin Med Date: 2022-06-07 Impact factor: 4.964