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Literature DB >> 30419515

Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.

Rasha E Shalaby¹, Saira Iram¹, Claudia E Oropeza¹, Alan McLachlan².

Abstract

Transcriptional coactivators represent critical components of the transcriptional pre-initiation complex and are required for efficient gene activation. Members of the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) family differentially regulate hepatitis b virus (HBV) biosynthesis. Whereas PGC1α has been shown to be a potent activator of HBV biosynthesis, PGC1β only very poorly activates HBV RNA and DNA synthesis in human hepatoma (HepG2) and embryonic kidney (HEK293T) cells. Furthermore, PGC1β inhibits PGC1α-mediated HBV biosynthesis. These observations suggest that a potential competition between human hepatoma (HepG2) and embryonic kidney (HEK293T) cells PGC1α and PGC1β for common transcription factor target(s) may regulate HBV transcription and replication in a context and signal transduction pathway dependent manner.

Entities: Chemical

Keywords: Coactivator competition; Hepatitis b virus; Peroxisome proliferator-activated receptor γ coactivator; Transcription coactivator; Transcription regulation; Viral replication

Mesh：

Substances：

Year: 2018 PMID： 30419515 PMCID： PMC6289603 DOI： 10.1016/j.virol.2018.10.027

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.513

59 in total

1. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.

Authors: Woojin An; Jaehoon Kim; Robert G Roeder
Journal: Cell Date: 2004-06-11 Impact factor: 41.582

2. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

Authors: Qihuang Jin; Li-Rong Yu; Lifeng Wang; Zhijing Zhang; Lawryn H Kasper; Ji-Eun Lee; Chaochen Wang; Paul K Brindle; Sharon Y R Dent; Kai Ge
Journal: EMBO J Date: 2010-12-03 Impact factor: 11.598

3. CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.

Authors: Jie Gao; Jiong Yan; Meishu Xu; Songrong Ren; Wen Xie
Journal: Mol Endocrinol Date: 2015-09-25

4. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

Authors: P Puigserver; Z Wu; C W Park; R Graves; M Wright; B M Spiegelman
Journal: Cell Date: 1998-03-20 Impact factor: 41.582

5. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.

Authors: D Knutti; A Kaul; A Kralli
Journal: Mol Cell Biol Date: 2000-04 Impact factor: 4.272

6. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.

Authors: Dieter Kressler; Sylvia N Schreiber; Darko Knutti; Anastasia Kralli
Journal: J Biol Chem Date: 2002-02-19 Impact factor: 5.157

7. Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1.

Authors: Shih-Ming Huang; Yi-Shan Cheng
Journal: Biochem J Date: 2004-08-15 Impact factor: 3.857

8. Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways.

Authors: Hongwei Li; Jeong Hoon Kim; Stephen S Koh; Michael R Stallcup
Journal: J Biol Chem Date: 2003-11-24 Impact factor: 5.157

Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.

1. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.

2. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.

3. CAR Suppresses Hepatic Gluconeogenesis by Facilitating the Ubiquitination and Degradation of PGC1α.

4. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.

5. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.

6. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.

7. Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1.

8. Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways.

9. Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids.

10. PGC-1beta in the regulation of hepatic glucose and energy metabolism.

1. Antiviral mechanism of preclinical antimalarial compounds possessing multiple antiviral activities.

Review 2. Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring.

3. β-Catenin Signaling Regulates the In Vivo Distribution of Hepatitis B Virus Biosynthesis across the Liver Lobule.