| Literature DB >> 30419351 |
Bruno Périchon1, Julie Guignot2, Noémi Szili1, Cherry Gao1, Claire Poyart3, Patrick Trieu-Cuot1, Shaynoor Dramsi4.
Abstract
The core PI-2b pilus present in "hypervirulent" ST-17 Streptococcus agalactiae strains consists of three pilin subunits (Spb1, Ap1 and Ap2) assembled by sortase SrtC1 and cell-wall anchored by Srt2. Spb1 was shown to be the major pilin and Ap2 the anchor pilin. Ap1 is a putative adhesin. Two additional genes, orf and lep, are part of this operon. The contribution of Lep and Ap1 to the biogenesis of the PI-2b pilus was investigated. Concerning the role of PI-2b, we found that higher PI-2b expression resulted in higher adherence to human brain endothelial cells and higher phagocytosis by human THP1 macrophages.Entities:
Keywords: GBS; Group B Streptococcus; PI-2b pilus; S. agalactiae; THP-1 phagocytosis
Mesh：
Substances：
Year: 2018 PMID： 30419351 DOI： 10.1016/j.micinf.2018.10.004
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700