Irwin Tendler1, Petr Brůža1, Jacqueline Andreozzi1, Michael Jermyn1, Benjamin Williams2, Lesley Jarvis3, Brian Pogue4, David Gladstone5. 1. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire. 2. Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. 3. Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Electronic address: lesley.a.jarvis@hitchcock.org. 4. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire. 5. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire; Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
Abstract
PURPOSE: The goal of this work is to produce a surface-dosimetry method capable of accurately and remotely measuring skin dose for patients undergoing total skin electron therapy (TSET) without the need for postexposure dosimeter processing. A rapid and wireless surface-dosimetry system was developed to improve clinical workflow. Scintillator-surface dosimetry was conducted on patients undergoing TSET by imaging scintillator targets with an intensified camera during TSET delivery. METHODS AND MATERIALS: Disc-shaped scintillator targets were attached to the skin surface of patients undergoing TSET and imaged with an intensified, time-gated, and linear accelerator-synchronized camera. Optically stimulated luminescence dosimeters (OSLDs) were placed directly adjacent to scintillators at several dosimetry sites to serve as an absolute dose reference. Real-time image-processing methods were used to produce background-subtracted intensity maps of Cherenkov and scintillation emission. Rapid conversion of scintillator-light output to dose was achieved by using a custom fitting algorithm and calibration factor. Surface doses measured by scintillators were compared with those from OSLDs. RESULTS: Absolute surface-dose measurements for 99 dosimetry sites were evaluated. According to paired OSLD estimates, scintillator dosimeters were able to report dose with <3% difference in 88 of 99 observed dosimetry sites and <5% difference in 98 of 99 observed dosimetry sites. Fitting a linear regression to dose data reported by scintillator versus OSLD, per dosimetry site, yielded an R2 = 0.94. CONCLUSIONS: Scintillators were able to report dose within <3% accuracy of OSLDs. Imaging of calibrated scintillator targets via an intensified, linear accelerator-synchronized camera provides rapid absolute surface-dosimetry measurements for patients treated with TSET. This technique has the potential to reduce the amount of time and effort necessary to conduct full-body dosimetry and can be adopted for use in any surface-dosimetry setting where the region of interest is observable throughout treatment.
PURPOSE: The goal of this work is to produce a surface-dosimetry method capable of accurately and remotely measuring skin dose for patients undergoing total skin electron therapy (TSET) without the need for postexposure dosimeter processing. A rapid and wireless surface-dosimetry system was developed to improve clinical workflow. Scintillator-surface dosimetry was conducted on patients undergoing TSET by imaging scintillator targets with an intensified camera during TSET delivery. METHODS AND MATERIALS: Disc-shaped scintillator targets were attached to the skin surface of patients undergoing TSET and imaged with an intensified, time-gated, and linear accelerator-synchronized camera. Optically stimulated luminescence dosimeters (OSLDs) were placed directly adjacent to scintillators at several dosimetry sites to serve as an absolute dose reference. Real-time image-processing methods were used to produce background-subtracted intensity maps of Cherenkov and scintillation emission. Rapid conversion of scintillator-light output to dose was achieved by using a custom fitting algorithm and calibration factor. Surface doses measured by scintillators were compared with those from OSLDs. RESULTS: Absolute surface-dose measurements for 99 dosimetry sites were evaluated. According to paired OSLD estimates, scintillator dosimeters were able to report dose with <3% difference in 88 of 99 observed dosimetry sites and <5% difference in 98 of 99 observed dosimetry sites. Fitting a linear regression to dose data reported by scintillator versus OSLD, per dosimetry site, yielded an R2 = 0.94. CONCLUSIONS: Scintillators were able to report dose within <3% accuracy of OSLDs. Imaging of calibrated scintillator targets via an intensified, linear accelerator-synchronized camera provides rapid absolute surface-dosimetry measurements for patients treated with TSET. This technique has the potential to reduce the amount of time and effort necessary to conduct full-body dosimetry and can be adopted for use in any surface-dosimetry setting where the region of interest is observable throughout treatment.
Authors: Jacqueline M Andreozzi; Petr Brůža; Jochen Cammin; Brian W Pogue; David J Gladstone; Olga Green Journal: Med Phys Date: 2019-12-25 Impact factor: 4.071
Authors: Yunhe Xie; Heather Petroccia; Amit Maity; Tianshun Miao; Yihua Zhu; Petr Bruza; Brian W Pogue; John P Plastaras; Lei Dong; Timothy C Zhu Journal: Med Phys Date: 2019-11-26 Impact factor: 4.071
Authors: Daniel A Alexander; Irwin I Tendler; Petr Bruza; Xu Cao; Philip E Schaner; Bethany S Marshall; Lesley A Jarvis; David J Gladstone; Brian W Pogue Journal: Phys Med Biol Date: 2019-07-18 Impact factor: 3.609
Authors: Irwin I Tendler; Petr Bruza; Michael Jermyn; Jennifer Soter; Gregory Sharp; Benjamin Williams; Lesley A Jarvis; Brian Pogue; David J Gladstone Journal: J Appl Clin Med Phys Date: 2020-04-19 Impact factor: 2.102
Authors: Irwin I Tendler; Petr Bruza; Michael Jermyn; Antoine Fleury; Benjamin B Williams; Lesley A Jarvis; Brian W Pogue; David J Gladstone Journal: J Biomed Opt Date: 2019-07 Impact factor: 3.170