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Literature DB >> 3041924

A double blind multicentre study of OM-8980 and auranofin in rheumatoid arthritis.

Abstract

The therapeutic efficacy of the immunomodulator OM-8980 in rheumatoid arthritis was compared with that of auranofin, an oral gold salt, in a double blind, randomised multicentre study lasting six months. Seventy patients were treated with auranofin and 75 with OM-8980. The patients of both groups improved significantly at three and six months for all the clinical parameters observed: Ritchie index, number of swollen joints, morning stiffness, pain, grip strength, intake of non-steroidal anti-inflammatory drugs, and erythrocyte sedimentation rate. No serious side effects were observed in either group. The patients receiving auranofin had more adverse reactions, mainly affecting the gastrointestinal system.

Entities: Chemical Disease Species

Mesh：

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Year: 1988 PMID： 3041924 PMCID： PMC1003574 DOI： 10.1136/ard.47.7.582

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

12 in total

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Journal: Rev Med Suisse Romande Date: 1981-02

A double blind multicentre study of OM-8980 and auranofin in rheumatoid arthritis.

1. 1958 REVISION of diagnostic criteria for rheumatoid arthritis.

2. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease.

3. Measurement of pain.

4. Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

5. Effect of a bacterial extract on cellular and humoral immune responses in humans.

6. [Effect of an oral polyvalent bacterial lysate (Broncho-Vaxom) in chronic bronchitis].

7. [Effect of a bacterial lysate (Broncho-Vaxom) in the therapy of chronic bronchitis: multi-center double-blind clinical trial].

8. Auranofin versus placebo in the treatment of rheumatoid arthritis.

9. Levamisole in rheumatoid arthritis--a multivariate analysis of a multicentric study.

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1. Follow-up with OM-8980 after a double-blind study of OM-8980 and auranofin in rheumatoid arthritis.

Review 2. Oral desensitisation in rheumatoid arthritis.

3. Intra-articular steroids: confounder of clinical trials.

4. Presence of hsp65 in bacterial extracts (OM-89): a possible mediator of orally-induced tolerance?

5. Double-blind, placebo-controlled study of OM-8980 in rheumatoid arthritis.