Literature DB >> 30418798

Epithelial-Stromal Interactions in Pancreatic Cancer.

Yaqing Zhang1, Howard C Crawford2,3, Marina Pasca di Magliano1,3,4.   

Abstract

Pancreatic cancer is characterized by an extensive fibroinflammatory reaction that includes immune cells, fibroblasts, extracellular matrix, vascular and lymphatic vessels, and nerves. Overwhelming evidence indicates that the pancreatic cancer microenvironment regulates cancer initiation, progression, and maintenance. Pancreatic cancer treatment has progressed little over the past several decades, and the prognosis remains one of the worst for any cancer. The contribution of the microenvironment to carcinogenesis is a key area of research, offering new potential targets for treating the disease. Here, we explore the composition of the pancreatic cancer stroma, discuss the network of interactions between different components, and describe recent attempts to target the stroma therapeutically. We also discuss current areas of active research related to the tumor microenvironment.

Entities:  

Keywords:  fibroblasts; pancreatic cancer; tumor microenvironment; tumor-associated macrophage; tumor-infiltrating lymphocytes

Mesh：

Year:  2018        PMID： 30418798     DOI： 10.1146/annurev-physiol-020518-114515

Source DB:  PubMed          Journal:  Annu Rev Physiol        ISSN： 0066-4278            Impact factor:   19.318


  14 in total

1.  A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.

Authors:  Corinna Cozzitorto; Laura Mueller; Silvia Ruzittu; Nancy Mah; David Willnow; Jean-Francois Darrigrand; Heather Wilson; Daniel Khosravinia; Amir-Ala Mahmoud; Maurizio Risolino; Licia Selleri; Francesca M Spagnoli
Journal:  Dev Cell       Date:  2020-08-27       Impact factor: 12.270

2.  Cancer associated fibroblast: Mediators of tumorigenesis.

Authors:  Jennifer Alexander; Edna Cukierman
Journal:  Matrix Biol       Date:  2020-05-22       Impact factor: 11.583

3.  A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity.

Authors:  Jaime Abrego; Hannah Sanford-Crane; Chet Oon; Xu Xiao; Courtney B Betts; Duanchen Sun; Shanthi Nagarajan; Luis Diaz; Holly Sandborg; Sohinee Bhattacharyya; Zheng Xia; Lisa M Coussens; Peter Tontonoz; Mara H Sherman
Journal:  Cancer Discov       Date:  2022-10-05       Impact factor: 38.272

Review 4.  Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma: Origin, Polarization, Function, and Reprogramming.

Authors:  Sen Yang; Qiaofei Liu; Quan Liao
Journal:  Front Cell Dev Biol       Date:  2021-01-11

5.  Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing.

Authors:  Nina Frey; Luigi Tortola; David Egli; Sharan Janjuha; Tanja Rothgangl; Kim Fabiano Marquart; Franziska Ampenberger; Manfred Kopf; Gerald Schwank
Journal:  Nat Commun       Date:  2022-04-04       Impact factor: 14.919

6.  Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer.

Authors:  Ashley M Mello; Tenzin Ngodup; Yusoo Lee; Katelyn L Donahue; Jinju Li; Arvind Rao; Eileen S Carpenter; Howard C Crawford; Marina Pasca di Magliano; Kyoung Eun Lee
Journal:  Oncogenesis       Date:  2022-09-15       Impact factor: 6.524

Review 7.  Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer.

Authors:  Wenting Du; Marina Pasca di Magliano; Yaqing Zhang
Journal:  Front Oncol       Date:  2021-07-05       Impact factor: 5.738

8.  Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1.

Authors:  Samantha B Kemp; Eileen S Carpenter; Nina G Steele; Katelyn L Donahue; Zeribe C Nwosu; Amanda Pacheco; Ashley Velez-Delgado; Rosa E Menjivar; Fatima Lima; Stephanie The; Carlos E Espinoza; Kristee Brown; Daniel Long; Costas A Lyssiotis; Arvind Rao; Yaqing Zhang; Marina Pasca di Magliano; Howard C Crawford
Journal:  Cancer Res       Date:  2021-05-28       Impact factor: 13.312

Review 9.  Pancreatic Fibroblast Heterogeneity: From Development to Cancer.

Authors:  Paloma E Garcia; Michael K Scales; Benjamin L Allen; Marina Pasca di Magliano
Journal:  Cells       Date:  2020-11-12       Impact factor: 6.600

10.  Hyaluronic acid fuels pancreatic cancer cell growth.

Authors:  Peter K Kim; Christopher J Halbrook; Samuel A Kerk; Megan Radyk; Stephanie Wisner; Daniel M Kremer; Peter Sajjakulnukit; Anthony Andren; Sean W Hou; Ayush Trivedi; Galloway Thurston; Abhinav Anand; Liang Yan; Lucia Salamanca-Cardona; Samuel D Welling; Li Zhang; Matthew R Pratt; Kayvan R Keshari; Haoqiang Ying; Costas A Lyssiotis
Journal:  Elife       Date:  2021-12-24       Impact factor: 8.713
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