| Literature DB >> 30417647 |
Tongxuan Bai1, Zhiyang Quan1, Rui Zhai1, Takayoshi Awakawa1,2, Yudai Matsuda1,3, Ikuro Abe1,2.
Abstract
The biosynthetic gene cluster of the fungal meroterpenoid chrodrimanin B (4) was discovered in Penicillium verruculosum TPU1311, and the complete biosynthetic pathway of 4 has been elucidated by heterologous reconstitution of its biosynthesis in Aspergillus oryzae, as well as by in vitro characterizations of selected enzymes. The present study has identified the polyketide synthase that produces 6-hydroxymellein (3) and also provided a biosynthetic platform of chrodrimanins for further bioengineering.Entities:
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Year: 2018 PMID： 30417647 DOI： 10.1021/acs.orglett.8b03268
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005