| Literature DB >> 30417374 |
Habib Yaribeygi1, Stephen L Atkin2, Amirhossein Sahebkar3,4,3.
Abstract
The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-α, and macrophage chemotactic protein-1; however, the role of IL-18 seems to be more specific than other cytokines in the inflammatory process. IL-18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression/urinary level of IL-18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate. In this review, we have focused on the molecular pathways modulating the relationship between IL-18 and diabetic nephropathy.Entities:
Keywords: apoptosis; diabetic nephropathy; inflammatory response; interleukin-18; oxidative stress; tumor necrosis factor-α
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Year: 2018 PMID： 30417374 DOI： 10.1002/jcp.27427
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384