An Hu1, Hai-Bin Liu2,3, Robert Mlynski2, Stefan Plontke4, Jing-Fei Zhang1, Wei-Jun Dai1, Jun-Li Duan5, Jing-Ping Fan3, Hong-Liang Zheng6, Wei-Hua Xu1, Xiao-Ping Chen1, Jing-Juan Huang7. 1. Department of Otolaryngology, Gongli Hospital, Second Military Medical University, Pudong New Area Miaopu Road 219, Shanghai, China. 2. Department of Otorhinolaryngology, Head and Neck Surgery "Otto Koerner", Rostock University Medical Center Gertrudenstraße 9, 18057 Rostock, Germany. 3. Department of Otolaryngology-Head and Neck Surgery, Changzheng Hospital, Second Military Medical University Fengyang Road 415, Huangpu District, Shanghai, China. 4. Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, University Medicine Halle Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany. 5. Department of Gerontology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine Kongjiang Road 1665, Shanghai, China. 6. Department of Otolaryngology-Head and Neck Surgery, Changhai Hospital, Second Military Medical University Changhai Road 168, Shanghai, China. 7. Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University Huaihai Xi Road 241, Xuhui District, Shanghai, China.
Abstract
Background: Postoperative pain has well defined and is perceived by patients as one of the most obnoxious aspects of surgical pain. The aim of this study was to determine whether the combination of Therapeutic ultrasound (TUS) and Curcumin (CUR) resulted in an enhancement of their pain relieving activities in a rat model of postoperative pain. Methods: We explored the effect of these treatment and their interaction with signal transduction pathways involved in inflammatory. In this study, TUS and CUR alone or in combination were administered prior to or simultaneously with or after the incisional surgery. Results: At the start time of administration, we observed that the TUS plus CUR treatment reduced the mean paw withdrawal threshold more efficiently than CUR alone. Then we demonstrated that TUS potentiates the antinociceptive effect of CUR in a rat model of chronic postoperative pain and that the combination could facilitate the recovery of surgical pain. However, preventive value was not statistically significant when the treatments were given prior to the incisional surgery. We provide evidence that TUS plus CUR administrations were safe and significantly reduced the ED50 compared to treatment with the single CUR treatment in rats. TUS plus CUR administrations decreases incisional surgery induced activation of inflammatory cells and down-regulation of chemokines and proinflammatory cytokines, MCP-1, MIP-1α, IL-1β, and TNF-α through regulating Sirt1/NF-κB signaling pathway. Conclusions: Taken together, our results indicate that the combinations of TUS and CUR can be more effective in the anti-nociceptive effects than the treatment with CUR alone.
Background: Postoperative pain has well defined and is perceived by patients as one of the most obnoxious aspects of surgical pain. The aim of this study was to determine whether the combination of Therapeutic ultrasound (TUS) and Curcumin (CUR) resulted in an enhancement of their pain relieving activities in a rat model of postoperative pain. Methods: We explored the effect of these treatment and their interaction with signal transduction pathways involved in inflammatory. In this study, TUS and CUR alone or in combination were administered prior to or simultaneously with or after the incisional surgery. Results: At the start time of administration, we observed that the TUS plus CUR treatment reduced the mean paw withdrawal threshold more efficiently than CUR alone. Then we demonstrated that TUS potentiates the antinociceptive effect of CUR in a rat model of chronic postoperative pain and that the combination could facilitate the recovery of surgical pain. However, preventive value was not statistically significant when the treatments were given prior to the incisional surgery. We provide evidence that TUS plus CUR administrations were safe and significantly reduced the ED50 compared to treatment with the single CUR treatment in rats. TUS plus CUR administrations decreases incisional surgery induced activation of inflammatory cells and down-regulation of chemokines and proinflammatory cytokines, MCP-1, MIP-1α, IL-1β, and TNF-α through regulating Sirt1/NF-κB signaling pathway. Conclusions: Taken together, our results indicate that the combinations of TUS and CUR can be more effective in the anti-nociceptive effects than the treatment with CUR alone.
Authors: Rachit Shah; Tsui-Fen Chou; Kimberly M Maize; Alexander Strom; Barry C Finzel; Carston R Wagner Journal: Biochem Biophys Res Commun Date: 2017-07-21 Impact factor: 3.575
Authors: Navneet Dhillon; Bharat B Aggarwal; Robert A Newman; Robert A Wolff; Ajaikumar B Kunnumakkara; James L Abbruzzese; Chaan S Ng; Vladimir Badmaev; Razelle Kurzrock Journal: Clin Cancer Res Date: 2008-07-15 Impact factor: 12.531