Cytoskeletal control of nuclear migration in neurons and non-neuronal cells.

Cell migration is a complex molecular event that requires translocation of a large, stiff nucleus, oftentimes through interstitial pores of submicron size in tissues. Remarkable progress in the past decade has uncovered an ever-increasing array of diverse nuclear dynamics and underlying cytoskeletal control in various cell models. In many cases, the microtubule motors dynein and kinesin directly interact with the nucleus via the LINC complex and steer directional nuclear movement, while actomyosin contractility and its global flow exert forces to deform and move the nucleus. In this review, I focus on the synergistic interplay of the cytoskeletal motors and spatiotemporal sites of force transmission in various nuclear migration models, with a special focus on neuronal migration in the vertebrate brain.