Literature DB >> 3041593

Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.

M C Rio1, J P Bellocq, J Y Daniel, C Tomasetto, R Lathe, M P Chenard, A Batzenschlager, P Chambon.   

Abstract

The human pS2 gene is specifically expressed under estrogen transcriptional control in a subclass of estrogen receptor-containing human breast cancer cells. The pS2 gene encodes an 84-amino acid protein that is secreted after signal peptide cleavage. The distribution of pS2 protein in normal human tissues was studied with antibodies to pS2; pS2 was specifically expressed and secreted by mucosa cells of the normal stomach antrum and body of both female and male individuals. Moreover, no estrogen receptor could be detected in these cells, indicating that pS2 gene expression is estrogen-independent in the stomach. The function of the pS2 protein in the gastrointestinal tract is unknown. However, the pS2 protein is similar in sequence to a porcine pancreatic protein that has been shown to inhibit gastrointestinal motility and gastric secretion.

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Year:  1988        PMID： 3041593     DOI： 10.1126/science.3041593

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  85 in total

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9.  Hyperplastic polyps: a cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage.

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10.  Immunohistochemical determination of pS2 in invasive breast carcinomas: a study on 942 cases.

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