Literature DB >> 30415470

WWP2 Is One Promising Novel Oncogene.

Rui Zhang1, Jianwu Zhang2, Wei Luo3, Zhuang Luo4, Shaoqing Shi5.   

Abstract

WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently accumulating evidences indicate that WWP2 plays a crucial part in the pathogenesis in different types of tumors. In this report, the role of this gene especially in tumorigenesis was reviewed. WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway. WWP2 also participates in anti-cancer agents' sensitivity, indicating WWP2 may be a novel target for cancer treatment. WWP2 is one promising novel oncogene.

Entities:  

Keywords:  Akt; Cancer; Pathogenesis; WWP2

Mesh：

Substances：

Year:  2018        PMID： 30415470     DOI： 10.1007/s12253-018-0506-5

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  7 in total

Review 1.  Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin.

Authors:  Jerry Vriend; Thomas Klonisch
Journal:  Cell Mol Neurobiol       Date:  2022-07-27       Impact factor: 4.231

2.  The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.

Authors:  Xinxin Lu; Xinyue Huang; Haiqi Xu; Saien Lu; Shilong You; Jiaqi Xu; Qianru Zhan; Chao Dong; Ning Zhang; Ying Zhang; Liu Cao; Xingang Zhang; Naijin Zhang; Lijun Zhang
Journal:  Cell Death Discov       Date:  2022-10-18

3.  The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.

Authors:  Eric Alix; Camilla Godlee; Ondrej Cerny; Samkeliso Blundell; Romina Tocci; Sophie Matthews; Mei Liu; Jonathan N Pruneda; Kirby N Swatek; David Komander; Tabitha Sleap; David W Holden
Journal:  Cell Host Microbe       Date:  2020-06-10       Impact factor: 21.023

4.  WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.

Authors:  Ying Zhang; Shilong You; Yichen Tian; Saien Lu; Liu Cao; Yingxian Sun; Naijin Zhang
Journal:  J Cell Mol Med       Date:  2020-07-05       Impact factor: 5.310

Review 5.  The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response.

Authors:  Xinxin Lu; Haiqi Xu; Jiaqi Xu; Saien Lu; Shilong You; Xinyue Huang; Naijin Zhang; Lijun Zhang
Journal:  Front Physiol       Date:  2022-08-26       Impact factor: 4.755

6.  Predicting the effect of 5-fluorouracil-based adjuvant chemotherapy on colorectal cancer recurrence: A model using gene expression profiles.

Authors:  Quan Chen; Peng Gao; Yongxi Song; Xuanzhang Huang; Qiong Xiao; Xiaowan Chen; Xinger Lv; Zhenning Wang
Journal:  Cancer Med       Date:  2020-03-09       Impact factor: 4.452

Review 7.  Potential of E3 Ubiquitin Ligases in Cancer Immunity: Opportunities and Challenges.

Authors:  Peng Ye; Xiaoxia Chi; Jong-Ho Cha; Shahang Luo; Guanghui Yang; Xiuwen Yan; Wen-Hao Yang
Journal:  Cells       Date:  2021-11-25       Impact factor: 6.600
  7 in total

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