| Literature DB >> 30414494 |
Jelena Kolosnjaj-Tabi1, Laure Gibot2, Isabelle Fourquaux3, Muriel Golzio2, Marie-Pierre Rols4.
Abstract
Electric fields are among physical stimuli that have revolutionized therapy. Occurring endogenously or exogenously, the electric field can be used as a trigger for controlled drug release from electroresponsive drug delivery systems, can stimulate wound healing and cell proliferation, may enhance endocytosis or guide stem cell differentiation. Electric field pulses may be applied to induce cell fusion, can increase the penetration of therapeutic agents into cells, or can be applied as a standalone therapy to ablate tumors. This review describes the main therapeutic trends and overviews the main physical, chemical and biological mechanisms underlying the actions of electric fields. Overall, the electric field can be used in therapeutic approaches in several ways. The electric field can act on drug carriers, cells and tissues. Understanding the multiple effects of this powerful tool will help harnessing its full therapeutic potential in an efficient and safe way.Entities:
Keywords: Conducting polymers; Electric field; Electro-responsive drug delivery; Electro-responsive hydrogels; Electrochemotherapy; Electropermeabilization; Irreversible electroporation
Mesh：
Year: 2018 PMID： 30414494 DOI： 10.1016/j.addr.2018.10.017
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470