| Literature DB >> 30414158 |
Abstract
In non-senescent Hydra, continuously high activity of transcription factor FOXO contributes to continuous stem cell proliferation. Here, we describe how genetic manipulation of Hydra polyps using embryo-microinjection allows uncovering the role of FOXO in coordinating both stem cell proliferation and antimicrobial peptide0073 , effector molecules of the innate immune system, and regulators of the microbiome.Entities:
Keywords: Aging; Antimicrobial peptides (AMPs); Embryo microinjection; FOXO; Hydra; Microbiome; Reporter gene constructs; Stem cells
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Year: 2019 PMID： 30414158 DOI： 10.1007/978-1-4939-8900-3_19
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745