Literature DB >> 30414045

Chronic vagal nerve stimulation exerts additional beneficial effects on the beta-blocker-treated failing heart.

Meihua Li1, Can Zheng2, Toru Kawada1, Masashi Inagaki1, Kazunori Uemura1, Masaru Sugimachi1.   

Abstract

Vagal nerve stimulation (VNS) induces bradycardia in chronic heart failure (CHF). We hypothesized that beta-blocker would cover the beneficial effects of VNS on CHF if the anti-beta-adrenergic effect was the main VNS effect. This study investigated the effects of VNS on cardiac remodeling in rats with CHF treated with metoprolol. Two weeks after myocardial infarction, surviving rats were randomly assigned to groups of sham stimulation (SS), sham stimulation with metoprolol (SSM), or VNS with metoprolol (VSM). Compared to the SS group, heart rate was significantly reduced in the SSM and VSM groups. Hemodynamic assessments showed that VSM rats maintained better cardiac pump function and presented higher cardiac index and lower heart weight than SSM rats. VSM was also associated with lower plasma brain natriuretic peptide and norepinephrine levels than SSM. VSM but not SSM improved the 50-day survival rate compared with the SS group. The results suggest that VNS may exert its beneficial effects on the failing heart independently of its anti-beta-adrenergic mechanism.

Entities:  

Keywords:  Beta-blocker; Cardiac remodeling; Chronic heart failure; Myocardial infarction; Vagal nerve stimulation

Mesh：

Substances：

Year:  2018        PMID： 30414045     DOI： 10.1007/s12576-018-0646-0

Source DB:  PubMed          Journal:  J Physiol Sci        ISSN： 1880-6546            Impact factor:   2.781


  40 in total

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  7 in total

1.  Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.

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2.  Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction.

Authors:  Meihua Li; Can Zheng; Toru Kawada; Kazunori Uemura; Masashi Inagaki; Keita Saku; Masaru Sugimachi
Journal:  J Physiol Sci       Date:  2022-06-20       Impact factor: 2.781

3.  Proteomics Reveals Long-Term Alterations in Signaling and Metabolic Pathways Following Both Myocardial Infarction and Chemically Induced Denervation.

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Journal:  Neurochem Res       Date:  2022-06-18       Impact factor: 4.414

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Authors:  Tomoko Uchino; Ming-Qi Zheng; Yan Wang; Katsushige Ono
Journal:  J Physiol Sci       Date:  2020-03-25       Impact factor: 2.781

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Authors:  Meihua Li; Can Zheng; Toru Kawada; Masashi Inagaki; Kazunori Uemura; Masaru Sugimachi
Journal:  J Physiol Sci       Date:  2020-02-17       Impact factor: 2.781
  7 in total

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