Literature DB >> 30413486

Seasonality in clinical courses of Kawasaki disease.

Daisuke Shimizu1, Takayuki Hoshina1, Masaru Kawamura1,2, Yoshie Tomita3, Yasufumi Hidaka4, Masumi Kojiro5, Jun Muneuchi6, Junji Kamizono3, Kenichiro Yamaguchi2, Yoshihisa Fujino7, Koichi Kusuhara1.   

Abstract

OBJECTIVE: Epidemics of Kawasaki disease (KD) are well known; however, the seasonal variation in the clinical course of KD is uncertain. The aim of this study was to investigate the seasonality in the clinical course of KD.
METHODS: This study included 744 patients who were admitted to six hospitals in Kitakyushu City for KD from 2010 to 2014. We divided the patients into two groups according to the average monthly temperature (warm and cold periods) and compared the clinical courses of KD.
RESULTS: The clinical courses of 715 patients who were initially treated with intravenous immunoglobulin (IVIG) were investigated. The proportion of patients with resistance to the initial IVIG therapy was significantly higher during the warm period than during the cold period (p=0.016). There was no seasonality in the proportion of patients with coronary artery abnormalities.
CONCLUSION: Seasonality was observed in the response to IVIG therapy of patients with KD. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  Kawasaki disease; coronary artery abnormality; refractory to high-dose intravenous immunoglobulin therapy; seasonality

Year:  2018        PMID： 30413486     DOI： 10.1136/archdischild-2018-315267

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  2 in total

1.  Non-coronary cardiac events, younger age, and IVIG unresponsiveness increase the risk for coronary aneurysms in Italian children with Kawasaki disease.

Authors:  Marianna Fabi; Laura Andreozzi; Ilaria Frabboni; Ada Dormi; Elena Corinaldesi; Francesca Lami; Cristina Cicero; Bertrand Tchana; Rosa Francavilla; Monica Sprocati; Barbara Bigucci; Claudia Balsamo; Paola Sogno Valin; Giorgia Di Fazzio; Lorenzo Iughetti; Enrico Valletta; Federico Marchetti; Andrea Donti; Marcello Lanari
Journal:  Clin Rheumatol       Date:  2020-09-16       Impact factor: 2.980

2.  The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease.

Authors:  Daisuke Shimizu; Takayuki Hoshina; Masaru Kawamura; Yoshie Tomita; Yasufumi Hidaka; Masumi Kojiro; Jun Muneuchi; Junji Kamizono; Kenichiro Yamaguchi; Yoshihisa Fujino; Koichi Kusuhara
Journal:  Front Pediatr       Date:  2022-09-06       Impact factor: 3.569
  2 in total

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