Hee Kyung Yang 1 , Sang Jun Park 1 , Seong Jun Byun 1 , Kyu Hyung Park 1 , Jeong-Whun Kim 2 , Jeong-Min Hwang 3 Show Affiliations »
Abstract
BACKGROUND/AIMS: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population. METHODS: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications. We applied Kaplan-Meier curves and Cox proportional hazard models to determine the risk of developing NAION in the OSA group compared with the non-OSA group. RESULTS: The 10-year incidence probability of NAION was higher in the OSA group (0.92%; 95% CI 0.88 to 0.97) than the non-OSA group (0.42%; 95% CI 0.41 to 0.44, p=0.002, log-rank test). The OSA group was at increased risk of developing NAION compared with the non-OSA group (HR 3.80; 95% CI 1.46 to 9.90) after adjusting for demographics, comorbidities and co-medications. CONCLUSIONS: Our results suggest that patients with newly diagnosed OSA have an increased risk of NAION, although the absolute risk of NAION is low. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
BACKGROUND/AIMS: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION ) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population. METHODS: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications. We applied Kaplan-Meier curves and Cox proportional hazard models to determine the risk of developing NAION in the OSA group compared with the non-OSA group. RESULTS: The 10-year incidence probability of NAION was higher in the OSA group (0.92%; 95% CI 0.88 to 0.97) than the non-OSA group (0.42%; 95% CI 0.41 to 0.44, p=0.002, log-rank test). The OSA group was at increased risk of developing NAION compared with the non-OSA group (HR 3.80; 95% CI 1.46 to 9 .90) after adjusting for demographics, comorbidities and co-medications. CONCLUSIONS: Our results suggest that patients with newly diagnosed OSA have an increased risk of NAION , although the absolute risk of NAION is low. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Entities: Chemical
Disease
Species
Keywords:
ischemic optic neuropathy; obstructive sleep apnea
Mesh： See more »
Year: 2018
PMID： 30413419 DOI： 10.1136/bjophthalmol-2018-312910
Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638