Jiawei Jiang1, Rui Liu2, Xin Yu1, Rui Yang1, Hua Xu3, Zhi Mao4, Yongqiang Wang5. 1. Department of Critical Care Medicine, Tianjin Medical University First Center Clinical College, Tianjin, People's Republic of China. 2. Department of Critical Care Medicine, Tangdu Hospital, Second Affiliated Hospital of Air Force Military Medical University, Xian, People's Republic of China. 3. Department of Critical Care Medicine, Tianjin First Center Hospital, Tianjin, People's Republic of China; Tianjin First Center Hospital Emergency Medical Research Institute, Tianjin, People's Republic of China. 4. Department of Critical Care Medicine, Chinese People's Liberation Army General Hospital, Beijing, People's Republic of China. 5. Department of Critical Care Medicine, Tianjin First Center Hospital, Tianjin, People's Republic of China; Tianjin First Center Hospital Emergency Medical Research Institute, Tianjin, People's Republic of China. Electronic address: yongqiangwang1962@sina.com.
Abstract
BACKGROUND: Bacteraemia is a common cause of increased morbidity and mortality in critically ill patients, but its early diagnosis and identification are complicated. The neutrophil-lymphocyte count ratio (NLCR) has been suggested as a useful indicator for the diagnosis of bacteraemia. We performed this meta-analysis to investigate the diagnostic accuracy of the NLCR for bacteraemia. METHODS: We searched the PubMed, Embase, Web of Science, and Cochrane Library databases for this meta-analysis. We calculated individual and pooled sensitivities and specificities. I2 statistics and Cochran's Q test were used to evaluate heterogeneity, and the cause of heterogeneity was explored with sensitivity analyses. RESULTS: In total, 8 of 1086 eligible articles were included in the present meta-analysis. The pooled analyses revealed that the diagnostic accuracy of the NLCR in terms of its bacteraemia sensitivity was 0.723 [95% CI: 0.660, 0.777], and its specificity was 0.596 [95% CI: 0.556, 0.634]. The area under the summary receiver operating characteristic curve was 0.69 [95% CI 0.65-0.73]. CONCLUSION: The NLCR is an easy-to-collect marker for bacteraemia. However, the NLCR is inadequate, and only a combination of multiple biomarkers will improve its diagnostic accuracy for bacteraemia.
BACKGROUND:Bacteraemia is a common cause of increased morbidity and mortality in critically illpatients, but its early diagnosis and identification are complicated. The neutrophil-lymphocyte count ratio (NLCR) has been suggested as a useful indicator for the diagnosis of bacteraemia. We performed this meta-analysis to investigate the diagnostic accuracy of the NLCR for bacteraemia. METHODS: We searched the PubMed, Embase, Web of Science, and Cochrane Library databases for this meta-analysis. We calculated individual and pooled sensitivities and specificities. I2 statistics and Cochran's Q test were used to evaluate heterogeneity, and the cause of heterogeneity was explored with sensitivity analyses. RESULTS: In total, 8 of 1086 eligible articles were included in the present meta-analysis. The pooled analyses revealed that the diagnostic accuracy of the NLCR in terms of its bacteraemia sensitivity was 0.723 [95% CI: 0.660, 0.777], and its specificity was 0.596 [95% CI: 0.556, 0.634]. The area under the summary receiver operating characteristic curve was 0.69 [95% CI 0.65-0.73]. CONCLUSION: The NLCR is an easy-to-collect marker for bacteraemia. However, the NLCR is inadequate, and only a combination of multiple biomarkers will improve its diagnostic accuracy for bacteraemia.
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