Minghua Tang1, Vivianne Andersen2, Audrey E Hendricks3, Nancy F Krebs4. 1. Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO. Electronic address: Minghua.Tang@ucdenver.edu. 2. University of Colorado School of Medicine, Aurora, CO. 3. Department of Mathematical and Statistical Science, University of Colorado Denver, Aurora, CO. 4. Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Abstract
OBJECTIVE: To test the long-term effect on growth statusat 24 months of age in formula-fed infants who were randomized to consume a meat- or dairy-based complementary diet from 5 to 12 months of age. STUDY DESIGN: Observational assessments, including anthropometric, dietary, and blood biomarkers, were conducted at 24 months of age, 1 year after the intervention ended. RESULTS: The retention rate at 24 months of age was 84% for the meat group and 81% for the dairy group. Mean (±SD) protein intakes at 24 months of age were 4.1 ± 1.2 and 4.0 ± 1.1 g/kmeat (n = 27) and dairy (n = 26) groups, respectively, and comparable with the estimates of US population intake. At 24 months of age, weight-for-age z score did not differ significantly between groups and was similar to that at 12 months. Length-for-age z score remained significantly higher in the meat group compared with the dairy group, and the average length was 1.9 cm greater in the meat group. Weight-for-length z score also did not differ significantly between groups. Insulin-like growth factor 1 significantly increased from 12 to 24 months of age in both groups, but insulin-like growth factor-binding protein 3 and blood urea nitrogen did not change significantly from 12 to 24 months of age and were comparable between groups. CONCLUSIONS: The protein source-induced distinctive growth patterns observed during infancy persisted at 24 months of age, suggesting a potential long-term impact of early protein quality on growth trajectories in formula-fed infants. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02142647.
RCT Entities:
OBJECTIVE: To test the long-term effect on growth status at 24 months of age in formula-fed infants who were randomized to consume a meat- or dairy-based complementary diet from 5 to 12 months of age. STUDY DESIGN: Observational assessments, including anthropometric, dietary, and blood biomarkers, were conducted at 24 months of age, 1 year after the intervention ended. RESULTS: The retention rate at 24 months of age was 84% for the meat group and 81% for the dairy group. Mean (±SD) protein intakes at 24 months of age were 4.1 ± 1.2 and 4.0 ± 1.1 g/kmeat (n = 27) and dairy (n = 26) groups, respectively, and comparable with the estimates of US population intake. At 24 months of age, weight-for-age z score did not differ significantly between groups and was similar to that at 12 months. Length-for-age z score remained significantly higher in the meat group compared with the dairy group, and the average length was 1.9 cm greater in the meat group. Weight-for-length z score also did not differ significantly between groups. Insulin-like growth factor 1 significantly increased from 12 to 24 months of age in both groups, but insulin-like growth factor-binding protein 3 and blood ureanitrogen did not change significantly from 12 to 24 months of age and were comparable between groups. CONCLUSIONS: The protein source-induced distinctive growth patterns observed during infancy persisted at 24 months of age, suggesting a potential long-term impact of early protein quality on growth trajectories in formula-fed infants. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02142647.
Authors: Minghua Tang; Nicholas E Weaver; Lillian M Berman; Laura D Brown; Audrey E Hendricks; Nancy F Krebs Journal: Nutrients Date: 2021-01-27 Impact factor: 5.717
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