| Literature DB >> 3041282 |
Abstract
The small nuclear RNA U6 and its gene have been isolated from yeast. In striking contrast to other yeast spliceosomal RNAs, U6 is very similar in size, sequence and structure to its mammalian homologue. The single-copy gene is essential. These properties suggest a central role in pre-mRNA processing. An extensive base-pairing interaction with U4 snRNA is described; the destabilization of the U4/U6 complex seen during splicing thus requires a large conformational change.Entities:
Mesh：
Substances：
Year: 1988 PMID： 3041282 DOI： 10.1038/334213a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962