| Literature DB >> 30411680 |
Shuai Fang1,2, Jinchang Pan1,2, Chengwei Zhou3, Hui Tian4, Jinxian He4, Weiyu Shen4, Xiaofeng Jin1,2, Xiaodan Meng1,2, Nan Jiang1,2, Zhaohui Gong1,2.
Abstract
Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) that structurally form closed loops without 5'-end cap and 3'-end poly(A) tail unlike linear RNAs. CircRNAs are widely present in eukaryotic cells with the capabilities of structural stability, high abundance and cell- /tissue-specific expression. A growing body of researches suggest that the dysregulated circRNAs are intimately relevant to the occurrence and development of cancer. In this review, we mainly discuss the differentially expressed circRNAs in cancer tissues, plasma and exosomes, which makes it possible for clinicians to use certain circRNAs as novel biomarkers for cancer diagnosis and prognosis. In particular, we primarily focus on circRNAs as potential therapeutic targets, which will provide promising applications in cancer gene therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: CircRNAs; biomarkers; cancer; circulating RNAs; differential expression; exosomes; therapeutic target.
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Year: 2019 PMID： 30411680 DOI： 10.2174/1566523218666181109142756
Source DB: PubMed Journal: Curr Gene Ther ISSN： 1566-5232 Impact factor: 4.391