Romain Breguet1,2, Federica Dondero3, Lawrence Pupulim4,5, Nicolas Goossens6, Ailton Sepulveda3, Claire Francoz7,8, François Durand7,8, Sylvain Terraz4,5, Valérie Vilgrain7,8, Maxime Ronot7,8. 1. Department of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland. romain.breguet@hcuge.ch. 2. Hepato-Pancreato-Biliary Centre, University Hospitals of Geneva, Geneva, Switzerland. romain.breguet@hcuge.ch. 3. Department of Hepatobiliopancreatic Surgery, Hôpital Beaujon, UNITY Hospitalo-Universitary Department, Hôpitaux Paris Nord Val de Seine (AP-HP), Clichy, France. 4. Department of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211, Geneva 14, Switzerland. 5. Hepato-Pancreato-Biliary Centre, University Hospitals of Geneva, Geneva, Switzerland. 6. Department of Gastroenterology and Hepatology, University Hospitals of Geneva, Geneva, Switzerland. 7. Department of Hepatology, Hôpital Beaujon, Hôpitaux Paris Nord Val de Seine (AP-HP), Clichy, France. 8. Sorbonne Paris Cité, CRI, U1149, Paris Diderot University, Paris, France.
Abstract
PURPOSE: To evaluate long-term arterial patency and abnormalities of bile ducts in patients that had endovascular treatment for arterial complications after liver transplantation (LT). MATERIALS AND METHODS: Between 2004 and 2014, 1048 LTs were consecutively performed in our institution and 53 patients (42 men; age range 19-69) were diagnosed and treated by endovascular techniques for arterial complications such as stenosis, thrombosis, dissection or kinking of the hepatic artery (HA). Radiological and surgical data were retrospectively analyzed, and survivors were contacted to undergo follow-up Doppler ultrasound (DUS) of the HA and magnetic resonance cholangiopancreatography. RESULTS: The primary technical success of endovascular treatment was 94% (n = 50). The patency rate of HA at 5-year was 81%. After a median follow-up of 58 months, 17 patients (32%) developed radiological features of ischemic cholangiopathy (IC), including 7 patients with abnormal DUS and 10 with normal DUS. Patients who presented with complications of the HA in the first 3 months after LT developed IC more frequently (42%) than others (12%) (p = 0.028). No other factor was associated with the development of IC. CONCLUSION: IC was more often observed when HA complication occurred within the first 3 months after LT. The presence of IC was not excluded by a normal DUS during follow-up.
PURPOSE: To evaluate long-term arterial patency and abnormalities of bile ducts in patients that had endovascular treatment for arterial complications after liver transplantation (LT). MATERIALS AND METHODS: Between 2004 and 2014, 1048 LTs were consecutively performed in our institution and 53 patients (42 men; age range 19-69) were diagnosed and treated by endovascular techniques for arterial complications such as stenosis, thrombosis, dissection or kinking of the hepatic artery (HA). Radiological and surgical data were retrospectively analyzed, and survivors were contacted to undergo follow-up Doppler ultrasound (DUS) of the HA and magnetic resonance cholangiopancreatography. RESULTS: The primary technical success of endovascular treatment was 94% (n = 50). The patency rate of HA at 5-year was 81%. After a median follow-up of 58 months, 17 patients (32%) developed radiological features of ischemic cholangiopathy (IC), including 7 patients with abnormal DUS and 10 with normal DUS. Patients who presented with complications of the HA in the first 3 months after LT developed IC more frequently (42%) than others (12%) (p = 0.028). No other factor was associated with the development of IC. CONCLUSION: IC was more often observed when HA complication occurred within the first 3 months after LT. The presence of IC was not excluded by a normal DUS during follow-up.