| Literature DB >> 30409859 |
Hae Woong Choi1, Jutamas Suwanpradid2, Il Hwan Kim3, Herman F Staats4,5,6, Muzlifah Haniffa7,8, Amanda S MacLeod2,5, Soman N Abraham4,5,9,10.
Abstract
Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.Entities:
Mesh：
Substances：
Year: 2018 PMID： 30409859 PMCID： PMC6376486 DOI： 10.1126/science.aao0666
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728