Hong Xie1, Meredith Claycomb Erwin2, Jon D Elhai2, John T Wall1, Marijo B Tamburrino3, Kristopher R Brickman4, Brian Kaminski5, Samuel A McLean6, Israel Liberzon7, Xin Wang8. 1. Department of Neurosciences, University of Toledo, Toledo, Ohio. 2. Department of Psychology, University of Toledo, Toledo, Ohio. 3. Department of Psychiatry, University of Toledo, Toledo, Ohio. 4. Department of Emergency Medicine, University of Toledo, Toledo, Ohio. 5. Department of Emergency Medicine, ProMedica Toledo Hospital, Toledo, Ohio. 6. Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 7. Department of Psychiatry, University of Michigan, Ann Arbor, Michigan. 8. Department of Psychiatry, University of Toledo, Toledo, Ohio. Electronic address: xin.wang2@utoledo.edu.
Abstract
BACKGROUND: Smaller hippocampal volume is associated with more severe posttraumatic stress disorder (PTSD) symptoms years after traumatic experiences. Posttraumatic stress symptoms appear early following trauma, but the relationship between hippocampal volume and PTSD symptom severity during early posttrauma periods is not well understood. It is possible that the inverse relationship between hippocampal volume and PTSD symptom severity is already present soon after trauma. To test this possibility, we prospectively examined the association between hippocampal volumes and severity of PTSD symptoms within weeks to months after trauma due to a motor vehicle collision. METHODS: Structural magnetic resonance imaging scans of 44 survivors were collected about 2 weeks and again at 3 months after a motor vehicle collision to measure hippocampal volumes. The PTSD Checklist was used to evaluate PTSD symptoms at each scan time. Full (n = 5) or partial (n = 6) PTSD was evaluated using the Clinician-Administered PTSD Scale at 3 months. RESULTS: Left hippocampal volumes at both time points negatively correlated with PTSD Checklist scores, and with subscores for re-experiencing symptoms at 3 months. Left hippocampal volumes at 3 months also negatively correlated with hyperarousal symptoms at 3 months. Finally, neither left nor right hippocampal volumes significantly changed between 2 weeks and 3 months posttrauma. CONCLUSIONS: The results suggest that small hippocampal volume at early posttrauma weeks is associated with increased risk for PTSD development. Furthermore, the inverse relationship between hippocampal volume and PTSD symptoms at 3 months did not arise from posttrauma shifts in hippocampal volume between 2 weeks and 3 months after trauma.
BACKGROUND: Smaller hippocampal volume is associated with more severe posttraumatic stress disorder (PTSD) symptoms years after traumatic experiences. Posttraumatic stress symptoms appear early following trauma, but the relationship between hippocampal volume and PTSD symptom severity during early posttrauma periods is not well understood. It is possible that the inverse relationship between hippocampal volume and PTSD symptom severity is already present soon after trauma. To test this possibility, we prospectively examined the association between hippocampal volumes and severity of PTSD symptoms within weeks to months after trauma due to a motor vehicle collision. METHODS: Structural magnetic resonance imaging scans of 44 survivors were collected about 2 weeks and again at 3 months after a motor vehicle collision to measure hippocampal volumes. The PTSD Checklist was used to evaluate PTSD symptoms at each scan time. Full (n = 5) or partial (n = 6) PTSD was evaluated using the Clinician-Administered PTSD Scale at 3 months. RESULTS: Left hippocampal volumes at both time points negatively correlated with PTSD Checklist scores, and with subscores for re-experiencing symptoms at 3 months. Left hippocampal volumes at 3 months also negatively correlated with hyperarousal symptoms at 3 months. Finally, neither left nor right hippocampal volumes significantly changed between 2 weeks and 3 months posttrauma. CONCLUSIONS: The results suggest that small hippocampal volume at early posttrauma weeks is associated with increased risk for PTSD development. Furthermore, the inverse relationship between hippocampal volume and PTSD symptoms at 3 months did not arise from posttrauma shifts in hippocampal volume between 2 weeks and 3 months after trauma.
Authors: Brigitte A Apfel; Jessica Ross; Jennifer Hlavin; Dieter J Meyerhoff; Thomas J Metzler; Charles R Marmar; Michael W Weiner; Norbert Schuff; Thomas C Neylan Journal: Biol Psychiatry Date: 2010-11-20 Impact factor: 13.382
Authors: Lies Clerx; Ed H B M Gronenschild; Carmen Echavarri; Frans Verhey; Pauline Aalten; Heidi I L Jacobs Journal: Curr Alzheimer Res Date: 2015 Impact factor: 3.498
Authors: Xin Wang; Hong Xie; Andrew S Cotton; Elizabeth R Duval; Marijo B Tamburrino; Kristopher R Brickman; Jon D Elhai; S Shaun Ho; Samuel A McLean; Eric J Ferguson; Israel Liberzon Journal: PLoS One Date: 2016-07-14 Impact factor: 3.240
Authors: Mark W Logue; Sanne J H van Rooij; Emily L Dennis; Sarah L Davis; Jasmeet P Hayes; Jennifer S Stevens; Maria Densmore; Courtney C Haswell; Jonathan Ipser; Saskia B J Koch; Mayuresh Korgaonkar; Lauren A M Lebois; Matthew Peverill; Justin T Baker; Premika S W Boedhoe; Jessie L Frijling; Staci A Gruber; Ilan Harpaz-Rotem; Neda Jahanshad; Sheri Koopowitz; Ifat Levy; Laura Nawijn; Lauren O'Connor; Miranda Olff; David H Salat; Margaret A Sheridan; Jeffrey M Spielberg; Mirjam van Zuiden; Sherry R Winternitz; Jonathan D Wolff; Erika J Wolf; Xin Wang; Kristen Wrocklage; Chadi G Abdallah; Richard A Bryant; Elbert Geuze; Tanja Jovanovic; Milissa L Kaufman; Anthony P King; John H Krystal; Jim Lagopoulos; Maxwell Bennett; Ruth Lanius; Israel Liberzon; Regina E McGlinchey; Katie A McLaughlin; William P Milberg; Mark W Miller; Kerry J Ressler; Dick J Veltman; Dan J Stein; Kathleen Thomaes; Paul M Thompson; Rajendra A Morey Journal: Biol Psychiatry Date: 2017-09-20 Impact factor: 12.810
Authors: Hong Xie; Nickelas Huffman; Chia-Hao Shih; Andrew S Cotton; Mark Buehler; Kristopher R Brickman; John T Wall; Xin Wang Journal: Psychiatry Res Neuroimaging Date: 2021-11-26 Impact factor: 2.376
Authors: Alyssa R Roeckner; Shivangi Sogani; Vasiliki Michopoulos; Rebecca Hinrichs; Sanne J H van Rooij; Barbara O Rothbaum; Tanja Jovanovic; Kerry J Ressler; Jennifer S Stevens Journal: Neuropsychopharmacology Date: 2022-09-16 Impact factor: 8.294
Authors: Alyssa R Roeckner; Katelyn I Oliver; Lauren A M Lebois; Sanne J H van Rooij; Jennifer S Stevens Journal: Transl Psychiatry Date: 2021-10-05 Impact factor: 6.222
Authors: Giorgia Picci; Nicholas J Christopher-Hayes; Nathan M Petro; Brittany K Taylor; Jacob A Eastman; Michaela R Frenzel; Yu-Ping Wang; Julia M Stephen; Vince D Calhoun; Tony W Wilson Journal: Neurobiol Stress Date: 2022-04-27
Authors: C N Weis; E K Webb; A A Huggins; M Kallenbach; T A Miskovich; J M Fitzgerald; K P Bennett; J L Krukowski; T A deRoon-Cassini; C L Larson Journal: Neuroimage Date: 2021-04-18 Impact factor: 6.556