Yiting Geng1, Danxia Zhu1, Chen Wu1, Jun Wu1, Qi Wang1, Ruiqi Li1, Jingting Jiang2, Changping Wu3. 1. Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, Jiangsu, China. 2. Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, Jiangsu, China. Electronic address: jiangjingting@suda.edu.cn. 3. Department of Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, Jiangsu, China; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou 213003, Jiangsu, China. Electronic address: wcpjjt@163.com.
Abstract
BACKGROUND: Inflammation is closely associated with the initiation and development of tumors. Based on the counts of peripheral neutrophils, monocytes and lymphocytes, we established a new systemic inflammation response index (SIRI) to predict postoperative survival of patients with esophageal squamous cell carcinoma (ESCC). METHODS: A total of 916 ESCC patients treated with radical esophagectomy were enrolled in the present study. RESULTS: Survival analysis indicated that the median overall survival (OS) in patients with SIRI≤1.2 was significantly higher than that in patients with SIRI>1.2. The nomogram including SIRI could more accurately predict OS compared with the TNM staging system. In addition, the changes of SIRI from baseline to 8 weeks after the operation were correlated with patient survival. The patients with an increase in SIRI >75% had worse OS compared with those with no change, while the patients with a decrease in SIRI >75% or in the scope of 25% ~75% exhibited better OS. CONCLUSIONS: SIRI was an independent prognostic index of ESCC patients after the radical resection. The nomogram integrating the SIRI could help clinicians to screen the high-risk patients and formulate the individualized treatment schemes.
BACKGROUND:Inflammation is closely associated with the initiation and development of tumors. Based on the counts of peripheral neutrophils, monocytes and lymphocytes, we established a new systemic inflammation response index (SIRI) to predict postoperative survival of patients with esophageal squamous cell carcinoma (ESCC). METHODS: A total of 916 ESCCpatients treated with radical esophagectomy were enrolled in the present study. RESULTS: Survival analysis indicated that the median overall survival (OS) in patients with SIRI≤1.2 was significantly higher than that in patients with SIRI>1.2. The nomogram including SIRI could more accurately predict OS compared with the TNM staging system. In addition, the changes of SIRI from baseline to 8 weeks after the operation were correlated with patient survival. The patients with an increase in SIRI >75% had worse OS compared with those with no change, while the patients with a decrease in SIRI >75% or in the scope of 25% ~75% exhibited better OS. CONCLUSIONS: SIRI was an independent prognostic index of ESCCpatients after the radical resection. The nomogram integrating the SIRI could help clinicians to screen the high-risk patients and formulate the individualized treatment schemes.
Authors: Cristina Valero; Daniella K Zanoni; Marlena R McGill; Ian Ganly; Luc G T Morris; Miquel Quer; Jatin P Shah; Richard J Wong; Xavier León; Snehal G Patel Journal: Cancer Date: 2019-12-06 Impact factor: 6.860