| Literature DB >> 30408584 |
Sheng Gao1, Yongdong Yi2, Guojun Xia2, Chengyang Yu2, Chenmin Ye2, Fuyang Tu2, Leibin Shen2, Wenqian Wang3, Chunyan Hua4.
Abstract
Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs. Autoimmune diseases are a family of chronic systemic inflammatory disorders. The pivotal role of TREM-1 in inflammation makes it important to explore its immunological effects in autoimmune diseases. In this review, we summarize the structural and functional characteristics of TREM-1. Particularly, we discuss recent findings on TREM-1 pathway regulation in various autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), type 1 diabetes (T1D), and psoriasis. This receptor may potentially be manipulated to alter the inflammatory response to chronic inflammation and possible therapies are explored in this review.Entities:
Keywords: Autoimmune disease; Inflammation; TREM-1; Therapy
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Year: 2018 PMID： 30408584 DOI： 10.1016/j.autrev.2018.07.008
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754