| Literature DB >> 30408565 |
Zachariah DeFilipp1, Elizabeth Hohmann2, Robert R Jenq3, Yi-Bin Chen4.
Abstract
Disruption of the intestinal microbiome early after allogeneic hematopoietic cell transplantation (allo-HCT) has been linked to adverse outcomes in transplant recipients. To date, whether microbiome-directed interventions will be able to impact important clinical endpoints remains unknown. Fecal microbiota transplantation (FMT) is a compelling intervention to restore healthy diversity to the intestinal microenvironment after allo-HCT, but currently has no established role in transplant recipients. In this review, we examine the use of FMT as treatment for Clostridium difficile infection and acute graft-versus-host disease, and also as a restorative intervention early after allo-HCT. Ongoing and planned studies will help determine the ultimate role of FMT in allo-HCT recipients.Entities:
Keywords: Allogeneic hematopoietic cell transplantation; Clostridium difficile infection; Fecal microbiota transplantation; Graft-versus-host disease; Microbiome
Mesh：
Year: 2018 PMID： 30408565 DOI： 10.1016/j.bbmt.2018.10.022
Source DB: PubMed Journal: Biol Blood Marrow Transplant ISSN： 1083-8791 Impact factor: 5.742