Literature DB >> 30408531

Modified gelatin nanoparticles for gene delivery.

Osama Madkhali1, George Mekhail2, Shawn D Wettig3.   

Abstract

Gelatin nanoparticles (GNPs) are one of the most extensively used natural polymers for gene therapy. With advantages of being biodegradable, biocompatible, low cost and easily modified, gelatin holds great promise as a non-viral system for gene delivery. This review examines various methods of preparation of modified gelatin nanoparticles and considers how these modifications apply to gene delivery. The article discusses cationic gelatin, PEGylated gelatin, thiolated gelatin, alendronate gelatin, and EGFR gelatin nanoparticles. This article also considers several advantages of these modifications and their contribution to the improvement in the efficiency of these systems, resulting in superior transfection and enhanced gene delivery in general.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Gelatin; Gene delivery; Method; Modification

Mesh：

Substances：

Year:  2018        PMID： 30408531     DOI： 10.1016/j.ijpharm.2018.11.001

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  10 in total

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  10 in total

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