N Caretta1, M De Rocco Ponce1, N Minicuci2, P Palego1, U Valente1, A Garolla1, A Ferlin3, C Foresta1. 1. Department of Medicine, Section of Endocrinology and Centre for Human Reproduction Pathology, University of Padova, Padua, Italy. 2. CNR, Neuroscience Institute, Padua, Italy. 3. Department of Clinical and Experimental Sciences, Endocrine and Metabolic Unit, University of Brescia, Brescia, Italy.
Abstract
BACKGROUND: Traditional risk factors used to assess cardiovascular risk miss a significant population who are indeed at risk for future cardiac events. Erectile dysfunction (ED) is an emerging marker for future cardiovascular disease (CVD) and major adverse cardiovascular events (MACE), especially in young and middle-aged men with vasculogenic ED. Cavernous arteries morphological alterations at penile colour doppler ultrasound (P-CDU) are used to find a vasculogenic ED. OBJECTIVES: We investigated the possible relationship between cavernous arteries morphological alterations at P-CDU assessment and future MACE. MATERIALS AND METHODS: We conducted a retrospective cohort study involving 300 ED patients, aged 35-65 years (mean age 54.1 ± 7.1), with a follow-up period of 10 years. Patients underwent vascular evaluation including P-CDU, colour doppler ultrasound of the carotid and lower limbs arteries. At baseline data for glucose metabolism, lipid profile, hypertension and hormonal status were collected. During the follow-up period, the occurrence of MACE was evaluated. RESULTS: We found a strong association between cavernous arteries morphological alterations and CVD with a threefold increased risk of future MACE in comparison to patients with healthy cavernous arteries (RR 3.2, 95% CI 1.17-8.78). This association remained statistically significant after adjustment for CV risk factors (age, glycaemia, total cholesterol, hypertension and smoke). CONCLUSIONS: Morphological alterations of cavernous arteries are independently associated with an increased risk of future MACE. These data contribute to the formulation of the hypothesis that cavernous artery pathology at P-CDU is related to MACE.
BACKGROUND: Traditional risk factors used to assess cardiovascular risk miss a significant population who are indeed at risk for future cardiac events. Erectile dysfunction (ED) is an emerging marker for future cardiovascular disease (CVD) and major adverse cardiovascular events (MACE), especially in young and middle-aged men with vasculogenic ED. Cavernous arteries morphological alterations at penile colour doppler ultrasound (P-CDU) are used to find a vasculogenic ED. OBJECTIVES: We investigated the possible relationship between cavernous arteries morphological alterations at P-CDU assessment and future MACE. MATERIALS AND METHODS: We conducted a retrospective cohort study involving 300 ED patients, aged 35-65 years (mean age 54.1 ± 7.1), with a follow-up period of 10 years. Patients underwent vascular evaluation including P-CDU, colour doppler ultrasound of the carotid and lower limbs arteries. At baseline data for glucose metabolism, lipid profile, hypertension and hormonal status were collected. During the follow-up period, the occurrence of MACE was evaluated. RESULTS: We found a strong association between cavernous arteries morphological alterations and CVD with a threefold increased risk of future MACE in comparison to patients with healthy cavernous arteries (RR 3.2, 95% CI 1.17-8.78). This association remained statistically significant after adjustment for CV risk factors (age, glycaemia, total cholesterol, hypertension and smoke). CONCLUSIONS: Morphological alterations of cavernous arteries are independently associated with an increased risk of future MACE. These data contribute to the formulation of the hypothesis that cavernous artery pathology at P-CDU is related to MACE.
Authors: Mohit Khera; Jeffrey K Than; James Anaissie; Ali Antar; Weitao Song; Boriss Losso; Alexander Pastuszak; Taylor Kohn; Jorge Rivera Mirabal Journal: Transl Androl Urol Date: 2020-06
Authors: Katelynn M Wilton; Sara J Achenbach; Paras Karmacharya; Floranne C Ernste; Eric L Matteson; Cynthia S Crowson Journal: J Rheumatol Date: 2020-10-15 Impact factor: 5.346
Authors: Maurizio De Rocco Ponce; Marco Vecchiato; Daniel Neunhaeuserer; Francesca Battista; Nicola Caretta; Francesco Savalla; Claudia Favero; Andrea Garolla; Carlo Foresta; Andrea Ermolao Journal: Sex Med Date: 2021-05-08 Impact factor: 2.523