Catharina S de Jonge1, Alex Menys2,3, Kyra L van Rijn1, Arjan J Bredenoord4, Aart J Nederveen1, Jaap Stoker1. 1. Department of Radiology and Nuclear Medicine, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2. Centre for Medical Imaging, University College London (UCL), London, UK. 3. Motilent, IDEALondon, London, UK. 4. Department of Gastroenterology and Hepatology, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: MRI is increasingly used to evaluate small bowel contractility. The objective of this study was to validate a clinically practical stimulation test (300-kcal meal) for small bowel motility. METHODS: Thirty-one healthy subjects underwent dynamic MRI to capture global small bowel motility after ±10h fasting, of which 15 underwent bowel preparation consisting of 1 L 2.5% mannitol solution and 16 did not. Each subject underwent (1) a baseline motility scan (2) a food challenge (3) a post-challenge scan, and (4) second post-challenge scan (after ±20 minutes). This protocol was repeated within 2 weeks. Motility was quantified using a validated motility assessment technique. KEY RESULTS: Motility in prepared subjects at baseline was significantly higher than motility in unprepared subjects (0.36 AU vs 0.18 AU, P < 0.001). In the prepared group, the food challenge produced an 8% increase in motility (P = 0.33) while in the unprepared subjects a significant increase of 30% was observed (P < 0.001). Responses to food remained insignificant (P = 0.21) and significant (P = 0.003), for the prepared and unprepared subjects, respectively, ±20 minutes post food challenge. These results were confirmed in the repeated scan session. CONCLUSION & INFERENCES: A significant response to a 300-kcal meal was measured within 10 minutes in unprepared bowel, supporting the clinical use of this challenge to provoke and assess motility changes. A caloric challenge did not produce an observable increase in motility in mannitol prepared subjects.
OBJECTIVE: MRI is increasingly used to evaluate small bowel contractility. The objective of this study was to validate a clinically practical stimulation test (300-kcal meal) for small bowel motility. METHODS: Thirty-one healthy subjects underwent dynamic MRI to capture global small bowel motility after ±10h fasting, of which 15 underwent bowel preparation consisting of 1 L 2.5% mannitol solution and 16 did not. Each subject underwent (1) a baseline motility scan (2) a food challenge (3) a post-challenge scan, and (4) second post-challenge scan (after ±20 minutes). This protocol was repeated within 2 weeks. Motility was quantified using a validated motility assessment technique. KEY RESULTS: Motility in prepared subjects at baseline was significantly higher than motility in unprepared subjects (0.36 AU vs 0.18 AU, P < 0.001). In the prepared group, the food challenge produced an 8% increase in motility (P = 0.33) while in the unprepared subjects a significant increase of 30% was observed (P < 0.001). Responses to food remained insignificant (P = 0.21) and significant (P = 0.003), for the prepared and unprepared subjects, respectively, ±20 minutes post food challenge. These results were confirmed in the repeated scan session. CONCLUSION & INFERENCES: A significant response to a 300-kcal meal was measured within 10 minutes in unprepared bowel, supporting the clinical use of this challenge to provoke and assess motility changes. A caloric challenge did not produce an observable increase in motility in mannitol prepared subjects.
Authors: Konstantinos C Fragkos; María Claudia Picasso Bouroncle; Shankar Kumar; Lucy Caselton; Alex Menys; Alan Bainbridge; Stuart A Taylor; Francisco Torrealdea; Tomoko Kumagai; Simona Di Caro; Farooq Rahman; Jane Macnaughtan; Manil D Chouhan; Shameer Mehta Journal: Nutrients Date: 2020-07-19 Impact factor: 5.717
Authors: Kyra L van Rijn; Albert J Bredenoord; André J P M Smout; Gerd Bouma; Jeroen A W Tielbeek; Karin Horsthuis; Jaap Stoker; Catharina S de Jonge Journal: Neurogastroenterol Motil Date: 2020-12-27 Impact factor: 3.598
Authors: Catharina S de Jonge; André M J Sprengers; Kyra L van Rijn; Aart J Nederveen; Jaap Stoker Journal: Neurogastroenterol Motil Date: 2019-12-11 Impact factor: 3.598