Rebecca C Hendrickson1,2, Abigail G Schindler3,4, Kathleen F Pagulayan5,3. 1. VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA. rhend@uw.edu. 2. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560 Room BB1644, Seattle, WA, 98195-6560, USA. rhend@uw.edu. 3. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560 Room BB1644, Seattle, WA, 98195-6560, USA. 4. Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA. 5. VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, S116 MIRECC, Seattle, WA, 98108, USA.
Abstract
PURPOSE OF REVIEW: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) can result from similar injuries and can result in similar symptoms, such as problems with sleep, concentration, memory, and mood. Although PTSD and persistent sequelae due to a TBI (PST) have generally been viewed as pragmatically confounded but conceptually separable entities, we examine emerging evidence emphasizing the breadth of overlap in both clinical presentation and underlying pathophysiology between PST and PTSD. RECENT FINDINGS: New evidence underscores the poor specificity of symptoms to etiology and emphasizes the potential, after both physical brain injury and traumatic stress, for changes in each of the three interacting systems that coordinate the body's response to the experience or expectation of major injury-the immune, endocrine, and neuromodulatory neurotransmitter systems. A view of PTSD and PST sharing common pathophysiologic elements related to the CNS response to acute injury or threat carries important implications for research and clinical care.
PURPOSE OF REVIEW: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) can result from similar injuries and can result in similar symptoms, such as problems with sleep, concentration, memory, and mood. Although PTSD and persistent sequelae due to a TBI (PST) have generally been viewed as pragmatically confounded but conceptually separable entities, we examine emerging evidence emphasizing the breadth of overlap in both clinical presentation and underlying pathophysiology between PST and PTSD. RECENT FINDINGS: New evidence underscores the poor specificity of symptoms to etiology and emphasizes the potential, after both physical brain injury and traumatic stress, for changes in each of the three interacting systems that coordinate the body's response to the experience or expectation of major injury-the immune, endocrine, and neuromodulatory neurotransmitter systems. A view of PTSD and PST sharing common pathophysiologic elements related to the CNS response to acute injury or threat carries important implications for research and clinical care.
Authors: K M Nylocks; V Michopoulos; A O Rothbaum; L Almli; C F Gillespie; A Wingo; A C Schwartz; L Habib; K L Gamwell; P J Marvar; B Bradley; K J Ressler Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2015-04-29 Impact factor: 3.568
Authors: Jeffrey R Strawn; Gail J Pyne-Geithman; Nosakhare N Ekhator; Paul S Horn; Thomas W Uhde; Lori A Shutter; Dewleen G Baker; Thomas D Geracioti Journal: Psychoneuroendocrinology Date: 2010-02-08 Impact factor: 4.905
Authors: Daniel B McKim; Jenna M Patterson; Eric S Wohleb; Brant L Jarrett; Brenda F Reader; Jonathan P Godbout; John F Sheridan Journal: Biol Psychiatry Date: 2015-07-26 Impact factor: 13.382
Authors: Charles W Wilkinson; Kathleen F Pagulayan; Eric C Petrie; Cynthia L Mayer; Elizabeth A Colasurdo; Jane B Shofer; Kim L Hart; David Hoff; Matthew A Tarabochia; Elaine R Peskind Journal: Front Neurol Date: 2012-02-07 Impact factor: 4.003
Authors: Joseph O Ojo; M Banks Greenberg; Paige Leary; Benoit Mouzon; Corbin Bachmeier; Michael Mullan; David M Diamond; Fiona Crawford Journal: Front Behav Neurosci Date: 2014-06-23 Impact factor: 3.558
Authors: Vikas Ghai; Shannon Fallen; David Baxter; Kelsey Scherler; Taek-Kyun Kim; Yong Zhou; James S Meabon; Aric F Logsdon; William A Banks; Abigail G Schindler; David G Cook; Elaine R Peskind; Inyoul Lee; Kai Wang Journal: J Neurotrauma Date: 2020-03-11 Impact factor: 5.269
Authors: Abigail G Schindler; Britahny Baskin; Barbara Juarez; Suhjung Janet Lee; Rebecca Hendrickson; Kathleen Pagulayan; Larry S Zweifel; Murray A Raskind; Paul E M Phillips; Elaine R Peskind; David G Cook Journal: Alcohol Clin Exp Res Date: 2021-04-09 Impact factor: 3.455
Authors: Brett S Schneider; David B Arciniegas; Carla Harenski; Gerard Janez Brett Clarke; Kent A Kiehl; Michael Koenigs Journal: Brain Inj Date: 2022-01-22 Impact factor: 2.311
Authors: Abigail G Schindler; Garth E Terry; Tami Wolden-Hanson; Marcella Cline; Michael Park; Janet Lee; Mayumi Yagi; James S Meabon; Elaine R Peskind; Murray M Raskind; Paul E M Phillips; David G Cook Journal: J Neurotrauma Date: 2020-12-16 Impact factor: 4.869
Authors: Arman Fesharaki-Zadeh; Jeremy T Miyauchi; Karrah St Laurent-Arriot; Stella E Tsirka; Peter J Bergold Journal: ASN Neuro Date: 2020 Jan-Dec Impact factor: 4.146
Authors: Britahny Baskin; Suhjung Janet Lee; Emma Skillen; Katrina Wong; Holly Rau; Rebecca C Hendrickson; Kathleen Pagulayan; Murray A Raskind; Elaine R Peskind; Paul E M Phillips; David G Cook; Abigail G Schindler Journal: Front Behav Neurosci Date: 2021-12-22 Impact factor: 3.558
Authors: Fabian Bockhop; Marina Zeldovich; Katrin Cunitz; Dominique Van Praag; Marjolein van der Vlegel; Tim Beissbarth; York Hagmayer; Nicole von Steinbuechel Journal: Sci Rep Date: 2022-10-04 Impact factor: 4.996