Literature DB >> 30405903

Computer aided design of FtsZ targeting oligopeptides†.

Stefano Rendine1, Chacko Jobichen2, Stefano Pieraccini1,3, Prerna Domadia2, J Sivaraman2, Pierangelo Francescato1, Giovanna Speranza1,3, Maurizio Sironi1,3.   

Abstract

FtsZ is a protein involved in the bacterial division process and is thus an emerging target for antibacterial drugs. The network of interactions between FtsZ monomers necessary for exploitation of its biological function are studied here with molecular dynamics and free energy calculations. The results obtained led to the design of FtsZ targeting peptides which exhibited activity against the function of FtsZ in vitro.

Entities:  

Year:  2012        PMID： 30405903      PMCID： PMC6217974          DOI： 10.1039/C2RA21886K

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  19 in total

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Journal:  Proteomics       Date:  2003-04       Impact factor: 3.984

2.  Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.

Authors:  Adelaine K W Leung; E Lucile White; Larry J Ross; Robert C Reynolds; Joseph A DeVito; David W Borhani
Journal:  J Mol Biol       Date:  2004-09-17       Impact factor: 5.469

Review 3.  Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

Authors:  Michelle R Arkin; James A Wells
Journal:  Nat Rev Drug Discov       Date:  2004-04       Impact factor: 84.694

4.  Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.

Authors:  Aaron A Handler; Joo Eun Lim; Richard Losick
Journal:  Mol Microbiol       Date:  2008-02-19       Impact factor: 3.501

5.  The bacteria fight back.

Authors:  Gary Taubes
Journal:  Science       Date:  2008-07-18       Impact factor: 47.728

6.  The stathmin-derived I19L peptide interacts with FtsZ and alters its bundling.

Authors:  Marie-Jeanne Clément; Boï-trinh Kuoch; Tap Ha-Duong; Vandana Joshi; Loïc Hamon; Flavio Toma; Patrick A Curmi; Philippe Savarin
Journal:  Biochemistry       Date:  2009-10-20       Impact factor: 3.162

7.  An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.

Authors:  David J Haydon; Neil R Stokes; Rebecca Ure; Greta Galbraith; James M Bennett; David R Brown; Patrick J Baker; Vladimir V Barynin; David W Rice; Sveta E Sedelnikova; Jonathan R Heal; Joseph M Sheridan; Sachin T Aiwale; Pramod K Chauhan; Anil Srivastava; Amit Taneja; Ian Collins; Jeff Errington; Lloyd G Czaplewski
Journal:  Science       Date:  2008-09-19       Impact factor: 47.728

Review 8.  Tubulin and FtsZ form a distinct family of GTPases.

Authors:  E Nogales; K H Downing; L A Amos; J Löwe
Journal:  Nat Struct Biol       Date:  1998-06

Review 9.  Bacterial cell division and the Z ring.

Authors:  J Lutkenhaus; S G Addinall
Journal:  Annu Rev Biochem       Date:  1997       Impact factor: 23.643

10.  Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde.

Authors:  Prerna Domadia; Sanjay Swarup; Anirban Bhunia; J Sivaraman; Debjani Dasgupta
Journal:  Biochem Pharmacol       Date:  2007-06-23       Impact factor: 5.858
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