Literature DB >> 30405872

Development of an Artificial Finger-Like Knee Loading Device to Promote Bone Health.

Sandeep Korupolu1, Stanley Chien2, Hiroki Yokota3, Sohel Anwar1.   

Abstract

This study presents the development of an innovative artificial finger-like device that provides position specific mechanical loads at the end of the long bone and induces mechanotransduction in bone. Bone cells such as osteoblasts are the mechanosensitive cells that regulate bone remodelling. When they receive gentle, periodic mechanical loads, new bone formation is promoted. The proposed device is an under-actuated multi-fingered artificial hand with 4 fingers, each having two phalanges. These fingers are connected by mechanical linkages and operated by a worm gearing mechanism. With the help of 3D printing technology, a prototype device was built mostly using plastic materials. The experimental validation results show that the device is capable of generating necessary forces at the desired frequencies, which are suitable for the stimulation of bone cells and the promotion of bone formation. It is recommended that the device be tested in a clinical study for confirming its safety and efficacy with patients.

Entities:  

Keywords:  Artificial Hand; Bone Growth; Mechanical Loading; Osteoblasts

Year:  2017        PMID: 30405872      PMCID: PMC6217823          DOI: 10.4236/jbise.2017.1011041

Source DB:  PubMed          Journal:  J Biomed Sci Eng        ISSN: 1937-6871


  10 in total

Review 1.  Osteoinduction, osteoconduction and osseointegration.

Authors:  T Albrektsson; C Johansson
Journal:  Eur Spine J       Date:  2001-10       Impact factor: 3.134

2.  Knee loading dynamically alters intramedullary pressure in mouse femora.

Authors:  Ping Zhang; Min Su; Yunlong Liu; Andrew Hsu; Hiroki Yokota
Journal:  Bone       Date:  2006-10-27       Impact factor: 4.398

3.  Bone deformation recorded in vivo from strain gauges attached to the human tibial shaft.

Authors:  L E Lanyon; W G Hampson; A E Goodship; J S Shah
Journal:  Acta Orthop Scand       Date:  1975-05

4.  Knee loading stimulates healing of mouse bone wounds in a femur neck.

Authors:  Ping Zhang; Hiroki Yokota
Journal:  Bone       Date:  2011-06-24       Impact factor: 4.398

5.  Pyrocarbon finger joint implant: an evidence-based analysis.

Authors: 
Journal:  Ont Health Technol Assess Ser       Date:  2004-03-01

6.  Development of a Portable Knee Rehabilitation Device That Uses Mechanical Loading.

Authors:  Daric Fitzwater; Todd Dodge; Stanley Chien; Hiroki Yokota; Sohel Anwar
Journal:  J Med Device       Date:  2013-09-24       Impact factor: 0.582

7.  Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles.

Authors:  Ping Zhang; Charles H Turner; Hiroki Yokota
Journal:  Bone       Date:  2009-02-07       Impact factor: 4.398

8.  Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulation.

Authors:  Engin Ozcivici; Yen K Luu; Clinton T Rubin; Stefan Judex
Journal:  PLoS One       Date:  2010-06-17       Impact factor: 3.240

Review 9.  Joint loading modality: its application to bone formation and fracture healing.

Authors:  P Zhang; G M Malacinski; H Yokota
Journal:  Br J Sports Med       Date:  2007-11-29       Impact factor: 13.800

10.  Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice.

Authors:  Ronald Y Kwon; Diana R Meays; W Joyce Tang; John A Frangos
Journal:  J Bone Miner Res       Date:  2010-08       Impact factor: 6.741

  10 in total

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