Literature DB >> 30405755

Effects of NOTCH1 signaling inhibitor γ-secretase inhibitor II on growth of cancer stem cells.

Xiaodong Ding1, Changqing Ding1, Fei Wang2, Wenshuai Deng1, Mingming Yu3, Qinghai Meng1, Peng Sun1.   

Abstract

The present study aimed to observe the effect of the Notch1 signaling inhibitor γ-secretase inhibitor II (GSI II) on the growth and differentiation of tumor cells. The tumor cell line U87 was grown in serum-free media, and cell growth was evaluated using immunofluorescence. Single-cell wall-adherent growing conditions were prepared, GSI II was added, and the differentiation and growth of single tumor cells was evaluated. Immunofluorescence demonstrated positive results for the expression of Nestin and cluster of differentiation 133. The cell proliferation rate was reduced following the addition of GSI II (P<0.05). GSI II may significantly inhibit the proliferation and differentiation of U87 tumor stem cells.

Entities:  

Keywords:  Notch1; brain tumor; stem cells; γ-secretase inhibitor II

Year:  2018        PMID： 30405755      PMCID： PMC6202534          DOI： 10.3892/ol.2018.9377

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  36 in total

1.  Effect of spinal cord extracts after spinal cord injury on proliferation of rat embryonic neural stem cells and Notch signal pathway in vitro.

Authors:  Qing-Zhong Zhou; Ge Zhang; Hai-Bo Long; Fei Lei; Fei Ye; Xu-Feng Jia; Yun-Long Zhou; Jian-Ping Kang; Da-Xiong Feng
Journal:  Asian Pac J Trop Med       Date:  2014-07       Impact factor: 1.226

2.  γ-Secretase inhibitor DAPT attenuates intimal hyperplasia of vein grafts by inhibition of Notch1 signaling.

Authors:  Yong Guang Xiao; Wei Wang; Dan Gong; Zhi Fu Mao
Journal:  Lab Invest       Date:  2014-04-21       Impact factor: 5.662

Review 3.  Notch: a key regulator of tumor angiogenesis and metastasis.

Authors:  Alejandro Garcia; Jessica J Kandel
Journal:  Histol Histopathol       Date:  2012-02       Impact factor: 2.303

Review 4.  Isolation and characterization of cancer stem cells in renal cell carcinoma.

Authors:  Giuseppe Lucarelli; Vanessa Galleggiante; Monica Rutigliano; Antonio Vavallo; Pasquale Ditonno; Michele Battaglia
Journal:  Urologia       Date:  2014-11-25

5.  Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

Authors:  Mariella Gruber Filbin; Sukriti K Dabral; Maria F Pazyra-Murphy; Shakti Ramkissoon; Andrew L Kung; Ekaterina Pak; Jarom Chung; Matthew A Theisen; Yanping Sun; Yoko Franchetti; Yu Sun; David S Shulman; Navid Redjal; Barbara Tabak; Rameen Beroukhim; Qi Wang; Jean Zhao; Marion Dorsch; Silvia Buonamici; Keith L Ligon; Joseph F Kelleher; Rosalind A Segal
Journal:  Nat Med       Date:  2013-09-29       Impact factor: 53.440

6.  Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation.

Authors:  Xiaohua Zhang; Tao Chen; Jiannan Zhang; Qin Mao; Shanquan Li; Wenhao Xiong; Yongming Qiu; Qiuling Xie; Jianwei Ge
Journal:  Cancer Sci       Date:  2011-12-15       Impact factor: 6.716

Review 7.  Nestin involvement in tissue injury and cancer--a potential tumor marker?

Authors:  Ekaterini Christina Tampaki; Lydia Nakopoulou; Athanasios Tampakis; Konstantinos Kontzoglou; Walter P Weber; Gregory Kouraklis
Journal:  Cell Oncol (Dordr)       Date:  2014-08-28       Impact factor: 6.730

8.  Molecular features of neural stem cells enable their enrichment using pharmacological inhibitors of survival-promoting kinases.

Authors:  Christine Y Brazel; Abdulaziz A Alaythan; Ryan J Felling; Frances Calderon; Steven W Levison
Journal:  J Neurochem       Date:  2013-10-10       Impact factor: 5.372

9.  Bmi-1 induces radioresistance by suppressing senescence in human U87 glioma cells.

Authors:  Lan Ye; Cuihong Wang; Guanying Yu; Yuhua Jiang; Dianshui Sun; Zaiyun Zhang; Xiaoming Yu; Xiaomei Li; Wei Wei; Ping Liu; Jian Cheng; Bin DU; Likuan Hu
Journal:  Oncol Lett       Date:  2014-10-10       Impact factor: 2.967

Review 10.  CD133 overexpression correlates with clinicopathological features of gastric cancer patients and its impact on survival: a systematic review and meta-analysis.

Authors:  Li Yiming; Guo Yunshan; Ma Bo; Zang Yu; Wei Tao; Liang Gengfang; Fan Dexian; Cui Shiqian; Jiang Jianli; Tang Juan; Chen Zhinan
Journal:  Oncotarget       Date:  2015-12-08
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  2 in total

Review 1.  Therapeutic targeting of the crosstalk between cancer-associated fibroblasts and cancer stem cells.

Authors:  Tu-Xiong Huang; Xin-Yuan Guan; Li Fu
Journal:  Am J Cancer Res       Date:  2019-09-01       Impact factor: 6.166

Review 2.  Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy.

Authors:  Maryam Ghanbari-Movahed; Zahra Ghanbari-Movahed; Saeideh Momtaz; Kaitlyn L Kilpatrick; Mohammad Hosein Farzaei; Anupam Bishayee
Journal:  Molecules       Date:  2021-02-12       Impact factor: 4.411
  2 in total

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