Jetta Kelppe1, Jaana Hagström1, Timo Sorsa2,3, Anna Liisa Suominen4,5, Satu Apajalahti6, Caj Haglund7, Hanna Thorén8,9. 1. Department of Pathology, Helsinki University and Helsinki University Hospital, Helsinki, Finland. 2. Department of Oral and Maxillofacial Diseases, Head and Neck Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 3. Department of Dental Medicine, Karolinska Institute, Huddinge, Sweden. 4. Institute of Dentistry, University of Eastern Finland, Kuopio, Finland. 5. Department of Oral and Maxillofacial Diseases, Kuopio University Hospital, Kuopio, Finland. 6. HUS Medical Imaging Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. 7. Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. 8. Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Turku, Turku, Finland. 9. Department of Oral and Maxillofacial Diseases, Turku University Hospital, Turku, Finland.
Abstract
Objective: This study aims to clarify demographic and clinical aspects of patients with ameloblastoma treated at a single Finnish institute during 1985-2016. Associations between predictor variables (gender and age) and outcome variables (location, tumour type, growth patterns and average tumour size) were sought.Materials and methods: A retrospective cohort study was designed and implemented including 34 patients diagnosed with primary ameloblastoma and treated at the Helsinki University Central Hospital. Patient records were investigated, and tissue samples re-evaluated. The chi-square test was used on all categorized variables and t-test for continuous ones. A p value equal to or under .05 was considered significant. Results: Males were slightly more predominant among the Finnish patients with ameloblastoma. Maxillary tumours were seen exclusively in male patients (p = .034). Additionally, these patients were older than patients with mandibular tumours (p = .007). A mixture in histological growth patterns was more common than originally anticipated. The study revealed a wide range of clinical signs and subjective symptoms, of which pain or other sensations were experienced most often.Conclusions: This study of 34 subjects shows that southern Finnish patients with ameloblastoma do not substantially differ from patients in similar study designs.
Objective: This study aims to clarify demographic and clinical aspects of patients with ameloblastoma treated at a single Finnish institute during 1985-2016. Associations between predictor variables (gender and age) and outcome variables (location, tumour type, growth patterns and average tumour size) were sought.Materials and methods: A retrospective cohort study was designed and implemented including 34 patients diagnosed with primary ameloblastoma and treated at the Helsinki University Central Hospital. Patient records were investigated, and tissue samples re-evaluated. The chi-square test was used on all categorized variables and t-test for continuous ones. A p value equal to or under .05 was considered significant. Results: Males were slightly more predominant among the Finnish patients with ameloblastoma. Maxillary tumours were seen exclusively in male patients (p = .034). Additionally, these patients were older than patients with mandibular tumours (p = .007). A mixture in histological growth patterns was more common than originally anticipated. The study revealed a wide range of clinical signs and subjective symptoms, of which pain or other sensations were experienced most often.Conclusions: This study of 34 subjects shows that southern Finnish patients with ameloblastoma do not substantially differ from patients in similar study designs.