Literature DB >> 30403991

Elusive Conformational Dynamics of PPARγ Inactivation Tied Down by Chemical Cross-Linking.

Jared P Mohr1, James E Bruce2.   

Abstract

In this issue of Structure, Zheng et al. (2018) have described the dynamics of PPARγ in complex with a non-agonist by exploring its solution-phase conformational landscape through chemical cross-linking in combination with a multitude of different treatment conditions, including their new synthetic anti-diabetic non-agonist, revealing the physical mechanism of PPARγ inactivation.
Copyright © 2018. Published by Elsevier Ltd.

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Year:  2018        PMID： 30403991      PMCID： PMC6516750          DOI： 10.1016/j.str.2018.10.015

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  10 in total

Review 1.  Estrogen receptors: how do they signal and what are their targets.

Authors:  Nina Heldring; Ashley Pike; Sandra Andersson; Jason Matthews; Guojun Cheng; Johan Hartman; Michel Tujague; Anders Ström; Eckardt Treuter; Margaret Warner; Jan-Ake Gustafsson
Journal:  Physiol Rev       Date:  2007-07       Impact factor: 37.312

2.  Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists.

Authors:  Alice Asteian; Anne-Laure Blayo; Yuanjun He; Marcel Koenig; Youseung Shin; Dana S Kuruvilla; Cesar A Corzo; Michael D Cameron; Li Lin; Claudia Ruiz; Susan Khan; Naresh Kumar; Scott Busby; David P Marciano; Ruben D Garcia-Ordonez; Patrick R Griffin; Theodore M Kamenecka
Journal:  ACS Med Chem Lett       Date:  2015-08-04       Impact factor: 4.345

3.  PPAR-gamma agonists and their role in type 2 diabetes mellitus management.

Authors:  Valmore Bermúdez; Freddy Finol; Nailyn Parra; Maria Parra; Adriana Pérez; Lianny Peñaranda; Daviel Vílchez; Joselyn Rojas; Nailet Arráiz; Manuel Velasco
Journal:  Am J Ther       Date:  2010 May-Jun       Impact factor: 2.688

4.  On the use of chemically derived distance constraints in the prediction of protein structure with myoglobin as an example.

Authors:  F E Cohen; M J Sternberg
Journal:  J Mol Biol       Date:  1980-02-15       Impact factor: 5.469

5.  Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation.

Authors:  B A Johnson; E M Wilson; Y Li; D E Moller; R G Smith; G Zhou
Journal:  J Mol Biol       Date:  2000-04-28       Impact factor: 5.469

6.  Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.

Authors:  Jie Zheng; Cesar Corzo; Mi Ra Chang; Jinsai Shang; Vinh Q Lam; Richard Brust; Anne-Laure Blayo; John B Bruning; Theodore M Kamenecka; Douglas J Kojetin; Patrick R Griffin
Journal:  Structure       Date:  2018-08-23       Impact factor: 5.006

7.  Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Authors:  Jang Hyun Choi; Alexander S Banks; Jennifer L Estall; Shingo Kajimura; Pontus Boström; Dina Laznik; Jorge L Ruas; Michael J Chalmers; Theodore M Kamenecka; Matthias Blüher; Patrick R Griffin; Bruce M Spiegelman
Journal:  Nature       Date:  2010-07-22       Impact factor: 49.962

8.  Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-gamma) agonist balaglitazone.

Authors:  Philip J Larsen; Kirsten Lykkegaard; Leif K Larsen; Jan Fleckner; Per Sauerberg; Karsten Wassermann; Erik Max Wulff
Journal:  Eur J Pharmacol       Date:  2008-08-16       Impact factor: 4.432

9.  Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Authors:  Jang Hyun Choi; Alexander S Banks; Theodore M Kamenecka; Scott A Busby; Michael J Chalmers; Naresh Kumar; Dana S Kuruvilla; Youseung Shin; Yuanjun He; John B Bruning; David P Marciano; Michael D Cameron; Dina Laznik; Michael J Jurczak; Stephan C Schürer; Dušica Vidović; Gerald I Shulman; Bruce M Spiegelman; Patrick R Griffin
Journal:  Nature       Date:  2011-09-04       Impact factor: 49.962

10.  PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.

Authors:  Rebecca L Frkic; Andrew C Marshall; Anne-Laure Blayo; Tara L Pukala; Theodore M Kamenecka; Patrick R Griffin; John B Bruning
Journal:  iScience       Date:  2018-07-02
  10 in total

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