Literature DB >> 30403644

Exploring Joint AB-LSTM With Embedded Lemmas for Adverse Drug Reaction Discovery.

Sara Santiso, Alicia Perez, Arantza Casillas.   

Abstract

This work focuses on the detection of adverse drug reactions (ADRs) in electronic health records (EHRs) written in Spanish. The World Health Organization underlines the importance of reporting ADRs for patients' safety. The fact is that ADRs tend to be under-reported in daily hospital praxis. In this context, automatic solutions based on text mining can help to alleviate the workload of experts. Nevertheless, these solutions pose two challenges: 1) EHRs show high lexical variability, the characterization of the events must be able to deal with unseen words or contexts and 2) ADRs are rare events, hence, the system should be robust against skewed class distribution. To tackle these challenges, deep neural networks seem appropriate because they allow a high-level representation. Specifically, we opted for a joint AB-LSTM network, a sub-class of the bidirectional long short-term memory network. Besides, in an attempt to reinforce lexical variability, we proposed the use of embeddings created using lemmas. We compared this approach with supervised event extraction approaches based on either symbolic or dense representations. Experimental results showed that the joint AB-LSTM approach outperformed previous approaches, achieving an f-measure of 73.3.

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Year:  2018        PMID: 30403644     DOI: 10.1109/JBHI.2018.2879744

Source DB:  PubMed          Journal:  IEEE J Biomed Health Inform        ISSN: 2168-2194            Impact factor:   5.772


  4 in total

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Authors:  Stephen Wu; Kirk Roberts; Surabhi Datta; Jingcheng Du; Zongcheng Ji; Yuqi Si; Sarvesh Soni; Qiong Wang; Qiang Wei; Yang Xiang; Bo Zhao; Hua Xu
Journal:  J Am Med Inform Assoc       Date:  2020-03-01       Impact factor: 4.497

2.  Deep learning detects and visualizes bleeding events in electronic health records.

Authors:  Jannik S Pedersen; Martin S Laursen; Thiusius Rajeeth Savarimuthu; Rasmus Søgaard Hansen; Anne Bryde Alnor; Kristian Voss Bjerre; Ina Mathilde Kjær; Charlotte Gils; Anne-Sofie Faarvang Thorsen; Eline Sandvig Andersen; Cathrine Brødsgaard Nielsen; Lou-Ann Christensen Andersen; Søren Andreas Just; Pernille Just Vinholt
Journal:  Res Pract Thromb Haemost       Date:  2021-05-05

3.  Adverse Drug Reaction Discovery Using a Tumor-Biomarker Knowledge Graph.

Authors:  Meng Wang; Xinyu Ma; Jingwen Si; Hongjia Tang; Haofen Wang; Tunliang Li; Wen Ouyang; Liying Gong; Yongzhong Tang; Xi He; Wei Huang; Xing Liu
Journal:  Front Genet       Date:  2021-01-12       Impact factor: 4.599

4.  Dependency Factors in Evidence Theory: An Analysis in an Information Fusion Scenario Applied in Adverse Drug Reactions.

Authors:  Luiz Alberto Pereira Afonso Ribeiro; Ana Cristina Bicharra Garcia; Paulo Sérgio Medeiros Dos Santos
Journal:  Sensors (Basel)       Date:  2022-03-16       Impact factor: 3.576

  4 in total

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