| Literature DB >> 30403475 |
Minghua Li1, Li Deng2, Jianbo Li2, Weizhong Yuan2, Xiaolong Gao1, Jiong Ni1, Hong Jiang1, Jiaqi Zeng1, Jie Ren2, Peijun Wang1.
Abstract
Nanodrug-delivery systems modified with targeting molecules allow antitumor drugs to localize to tumor sites efficiently. CD147 protein is expressed highly on hepatoma cells. Firstly, we synthesized magnetothermally responsive nanocarriers/doxorubicin (MTRN/DOX) which was composed of manganese zinc (Mn-Zn) ferrite magnetic nanoparticles, amphiphilic and thermosensitivity copolymer drug carriers together with DOX. Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein. It could target hepatoma cells actively and improve the DOX concentration in the tumor sites. Subsequently, an external alternating magnetic field elevated the temperature of the thermomagnetic particles, resulting in structural changes in the thermosensitive copolymer drug carriers, thereby releasing DOX. Hence, CD147-MTRN/DOX could enhance the responsiveness of hepatoma cells to the pre-existing chemotherapy drugs owing to active targeting combined synergistically with thermotherapy and chemotherapy, which has more significant anticancer effects than MTRN/DOX.Entities:
Keywords: active targeting; cancer combined therapy; drug delivery; magnetic hyperthermia; magnetic nanoparticles
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Year: 2018 PMID： 30403475 DOI： 10.1021/acsami.8b14972
Source DB: PubMed Journal: ACS Appl Mater Interfaces ISSN： 1944-8244 Impact factor: 9.229