Literature DB >> 304033

The influence of antigen presentation on the generation of T-helper cells with different functions.

H Waldmann, H Pope.   

Abstract

Thymocytes adoptively transferred into syngeneic irradiated recipients can be primed with antigen (KLH) to generate two types of helper function termed 'specific' and 'non-specific'. Low doses of KLH given without adjuvant generate high levels of non-specific compared to 'specific' helper T cells. Large doses of KLH given in adjuvant (FCA) generate high levels of both types of helper T cell. Explantations for this observation are discussed.

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Year:  1977        PMID： 304033      PMCID： PMC1445528     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  7 in total

1.  The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.

Authors:  N A Mitchison
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

2.  T cell dependence of B cell unresponsiveness in vitro.

Authors:  H Waldmann; A J Munro
Journal:  Eur J Immunol       Date:  1974-06       Impact factor: 5.532

3.  Induction of antibody-forming cell clones in microcultures.

Authors:  I Lefkovits
Journal:  Eur J Immunol       Date:  1972-08       Impact factor: 5.532

4.  A rapid method for the isolation of functional thymus-derived murine lymphocytes.

Authors:  M H Julius; E Simpson; L A Herzenberg
Journal:  Eur J Immunol       Date:  1973-10       Impact factor: 5.532

5.  Restriction in the function of single helper T cells.

Authors:  H Waldmann; I Lefkovits; A Feinstein
Journal:  Immunology       Date:  1976-09       Impact factor: 7.397

6.  Antigen-specific and nonspecific mediatiors of T cell/B cell cooperation. II. Two helper T cells distinguished by their antigen sensitivities.

Authors:  P Marrack; J W Kappler
Journal:  J Immunol       Date:  1976-05       Impact factor: 5.422

7.  Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

Authors:  P C Marrack; J W Kappler
Journal:  J Immunol       Date:  1975-03       Impact factor: 5.422
  7 in total
  2 in total

1.  T cell help mechanisms in the in vitro antibody response: the role of linked and non-linked recognition interactions.

Authors:  C P Sullivan; H Waldmann
Journal:  Immunology       Date:  1984-02       Impact factor: 7.397

Review 2.  How many T cells help one B cell?

Authors:  H Waldmann; J Phillips
Journal:  Springer Semin Immunopathol       Date:  1980-05
  2 in total

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