Huafu Wang1, Huang Gang2, Shuxin Zhou3, Lixian Liu1, Ting Ding1, Zhihong Gui4, Weihua Chu2. 1. Department of pharmacy, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China. 2. Department of Traditional Chinese Medicine, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China. 3. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, P.R. China. 4. Department of Nephrology, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Abstract
OBJECTIVE: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China. METHODS: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed. RESULTS: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabetic mice. CONCLUSION: This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model.
OBJECTIVE: Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China. METHODS: In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabeticmice was also analyzed. RESULTS: LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabeticmice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabeticmice. CONCLUSION: This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model.