| Literature DB >> 3040224 |
A Aoyama, S Nagayoshi, S Saga, J Malavasi-Yamashiro, T Yokoi, T Takenaka, O Miyaishi, J Lu, M Imai, T Tomita.
Abstract
Although II-TES mice release large amounts of murine mammary tumor virus (MMTV) in milk, they are resistant to mammary tumorigenesis. High mammary tumor incidence was observed in (BALB/ca X II-TES)F1 and (C57BL/6N X II-TES)F1, whereas no mammary tumors developed in BALB/ca X OZ-F)F1. Mammary tumors developed in 68% of (OZ-F X (OZ-F X II-TES)F1 and 45% of (II-TES X (OZ-F X II-TES)F1). These results suggest that the II-TES mouse carries a recessive gene for mammary tumor resistance which does not inhibit MMTV release, and two independent dominant mammary tumor promoting genes which are inhibited by the resistant gene.Entities:
Mesh：
Year: 1987 PMID： 3040224 DOI： 10.1016/0304-3835(87)90082-6
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679