Literature DB >> 30401750

An improbable journey: Creativity helped me make the transition from art to curing malaria.

Elizabeth A Winzeler1.   

Abstract

I was recently awarded the Alice and C. C. Wang Award in Molecular Parasitology for my contributions to antimalarial drug development, including laying the groundbreaking work that has led to two new molecular methods for curing malaria. This award means a great deal to me because I have spent much of my scientific career feeling like an imposter-one with the wrong sort of background and poor credentials. I am grateful for the recognition, and I am beginning to recognize that having an atypical background can be an advantage because it gives you a different perspective on a challenge. More generally, diversity in educational and cultural backgrounds is important because it can stimulate new ways of thinking and discovery.
© 2019 Winzeler.

Entities:  

Keywords:  Plasmodium; career choices; chemical biology; diversity in science; drug development; education; genomics; imposter syndrome; malaria; microbiology

Mesh:

Substances:

Year:  2018        PMID: 30401750      PMCID: PMC6333892          DOI: 10.1074/jbc.AW118.005229

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  19 in total

1.  Replication dynamics of the yeast genome.

Authors:  M K Raghuraman; E A Winzeler; D Collingwood; S Hunt; L Wodicka; A Conway; D J Lockhart; R W Davis; B J Brewer; W L Fangman
Journal:  Science       Date:  2001-10-05       Impact factor: 47.728

2.  Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.

Authors:  Stephan Meister; David M Plouffe; Kelli L Kuhen; Ghislain M C Bonamy; Tao Wu; S Whitney Barnes; Selina E Bopp; Rachel Borboa; A Taylor Bright; Jianwei Che; Steve Cohen; Neekesh V Dharia; Kerstin Gagaring; Montip Gettayacamin; Perry Gordon; Todd Groessl; Nobutaka Kato; Marcus C S Lee; Case W McNamara; David A Fidock; Advait Nagle; Tae-gyu Nam; Wendy Richmond; Jason Roland; Matthias Rottmann; Bin Zhou; Patrick Froissard; Richard J Glynne; Dominique Mazier; Jetsumon Sattabongkot; Peter G Schultz; Tove Tuntland; John R Walker; Yingyao Zhou; Arnab Chatterjee; Thierry T Diagana; Elizabeth A Winzeler
Journal:  Science       Date:  2011-11-17       Impact factor: 47.728

3.  Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Authors:  Nobutaka Kato; Eamon Comer; Tomoyo Sakata-Kato; Arvind Sharma; Manmohan Sharma; Micah Maetani; Jessica Bastien; Nicolas M Brancucci; Joshua A Bittker; Victoria Corey; David Clarke; Emily R Derbyshire; Gillian L Dornan; Sandra Duffy; Sean Eckley; Maurice A Itoe; Karin M J Koolen; Timothy A Lewis; Ping S Lui; Amanda K Lukens; Emily Lund; Sandra March; Elamaran Meibalan; Bennett C Meier; Jacob A McPhail; Branko Mitasev; Eli L Moss; Morgane Sayes; Yvonne Van Gessel; Mathias J Wawer; Takashi Yoshinaga; Anne-Marie Zeeman; Vicky M Avery; Sangeeta N Bhatia; John E Burke; Flaminia Catteruccia; Jon C Clardy; Paul A Clemons; Koen J Dechering; Jeremy R Duvall; Michael A Foley; Fabian Gusovsky; Clemens H M Kocken; Matthias Marti; Marshall L Morningstar; Benito Munoz; Daniel E Neafsey; Amit Sharma; Elizabeth A Winzeler; Dyann F Wirth; Christina A Scherer; Stuart L Schreiber
Journal:  Nature       Date:  2016-09-07       Impact factor: 49.962

4.  In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Authors:  David Plouffe; Achim Brinker; Case McNamara; Kerstin Henson; Nobutaka Kato; Kelli Kuhen; Advait Nagle; Francisco Adrián; Jason T Matzen; Paul Anderson; Tae-Gyu Nam; Nathanael S Gray; Arnab Chatterjee; Jeff Janes; S Frank Yan; Richard Trager; Jeremy S Caldwell; Peter G Schultz; Yingyao Zhou; Elizabeth A Winzeler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-25       Impact factor: 11.205

5.  Spiroindolone KAE609 for falciparum and vivax malaria.

Authors:  Nicholas J White; Sasithon Pukrittayakamee; Aung Pyae Phyo; Ronnatrai Rueangweerayut; François Nosten; Podjanee Jittamala; Atthanee Jeeyapant; Jay Prakash Jain; Gilbert Lefèvre; Ruobing Li; Baldur Magnusson; Thierry T Diagana; F Joel Leong
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

6.  High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.

Authors:  Justine Swann; Victoria Corey; Christina A Scherer; Nobutaka Kato; Eamon Comer; Micah Maetani; Yevgeniya Antonova-Koch; Christin Reimer; Kerstin Gagaring; Maureen Ibanez; David Plouffe; Anne-Marie Zeeman; Clemens H M Kocken; Case W McNamara; Stuart L Schreiber; Brice Campo; Elizabeth A Winzeler; Stephan Meister
Journal:  ACS Infect Dis       Date:  2016-02-10       Impact factor: 5.084

7.  Discovery of gene function by expression profiling of the malaria parasite life cycle.

Authors:  Karine G Le Roch; Yingyao Zhou; Peter L Blair; Muni Grainger; J Kathleen Moch; J David Haynes; Patricia De La Vega; Anthony A Holder; Serge Batalov; Daniel J Carucci; Elizabeth A Winzeler
Journal:  Science       Date:  2003-07-31       Impact factor: 47.728

8.  Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.

Authors:  Selina E R Bopp; Micah J Manary; A Taylor Bright; Geoffrey L Johnston; Neekesh V Dharia; Fabio L Luna; Susan McCormack; David Plouffe; Case W McNamara; John R Walker; David A Fidock; Eros Lazzerini Denchi; Elizabeth A Winzeler
Journal:  PLoS Genet       Date:  2013-02-07       Impact factor: 5.917

9.  A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Authors:  Beatriz Baragaña; Irene Hallyburton; Marcus C S Lee; Neil R Norcross; Raffaella Grimaldi; Thomas D Otto; William R Proto; Andrew M Blagborough; Stephan Meister; Grennady Wirjanata; Andrea Ruecker; Leanna M Upton; Tara S Abraham; Mariana J Almeida; Anupam Pradhan; Achim Porzelle; María Santos Martínez; Torsten Luksch; Judith M Bolscher; Andrew Woodland; Suzanne Norval; Fabio Zuccotto; John Thomas; Frederick Simeons; Laste Stojanovski; Maria Osuna-Cabello; Paddy M Brock; Tom S Churcher; Katarzyna A Sala; Sara E Zakutansky; María Belén Jiménez-Díaz; Laura Maria Sanz; Jennifer Riley; Rajshekhar Basak; Michael Campbell; Vicky M Avery; Robert W Sauerwein; Koen J Dechering; Rintis Noviyanti; Brice Campo; Julie A Frearson; Iñigo Angulo-Barturen; Santiago Ferrer-Bazaga; Francisco Javier Gamo; Paul G Wyatt; Didier Leroy; Peter Siegl; Michael J Delves; Dennis E Kyle; Sergio Wittlin; Jutta Marfurt; Ric N Price; Robert E Sinden; Elizabeth A Winzeler; Susan A Charman; Lidiya Bebrevska; David W Gray; Simon Campbell; Alan H Fairlamb; Paul A Willis; Julian C Rayner; David A Fidock; Kevin D Read; Ian H Gilbert
Journal:  Nature       Date:  2015-06-18       Impact factor: 49.962

10.  High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.

Authors:  David M Plouffe; Melanie Wree; Alan Y Du; Stephan Meister; Fengwu Li; Kailash Patra; Aristea Lubar; Shinji L Okitsu; Erika L Flannery; Nobutaka Kato; Olga Tanaseichuk; Eamon Comer; Bin Zhou; Kelli Kuhen; Yingyao Zhou; Didier Leroy; Stuart L Schreiber; Christina A Scherer; Joseph Vinetz; Elizabeth A Winzeler
Journal:  Cell Host Microbe       Date:  2015-12-31       Impact factor: 21.023

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