Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Histone Acetylation Inhibits RSC and Stabilizes the +1 Nucleosome.

Literature DB >> 30401433

Histone Acetylation Inhibits RSC and Stabilizes the +1 Nucleosome.

Yahli Lorch¹, Barbara Maier-Davis², Roger D Kornberg².

Abstract

The +1 nucleosome of yeast genes, within which reside transcription start sites, is characterized by histone acetylation, by the displacement of an H2A-H2B dimer, and by a persistent association with the RSC chromatin-remodeling complex. Here we demonstrate the interrelationship of these characteristics and the conversion of a nucleosome to the +1 state in vitro. Contrary to expectation, acetylation performs an inhibitory role, preventing the removal of a nucleosome by RSC. Inhibition is due to both enhanced RSC-histone interaction and diminished histone-chaperone interaction. Acetylation does not prevent all RSC activity, because stably bound RSC removes an H2A-H2B dimer on a timescale of seconds in an irreversible manner.

Entities: Chemical Disease Gene Species

Keywords: NAP1; NuA4; SAGA; chromatin; chromatin-remodeling; transcription

Mesh：

Substances：

Year: 2018 PMID： 30401433 PMCID： PMC6290470 DOI： 10.1016/j.molcel.2018.09.030

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

45 in total

1. Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.

Authors: Huck Hui Ng; François Robert; Richard A Young; Kevin Struhl
Journal: Genes Dev Date: 2002-04-01 Impact factor: 11.361

2. Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.

Authors: Huck Hui Ng; François Robert; Richard A Young; Kevin Struhl
Journal: Mol Cell Date: 2003-03 Impact factor: 17.970

3. RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation.

Authors: Michael Carey; Bing Li; Jerry L Workman
Journal: Mol Cell Date: 2006-11-03 Impact factor: 17.970

4. Genome-scale identification of nucleosome positions in S. cerevisiae.

Authors: Guo-Cheng Yuan; Yuen-Jong Liu; Michael F Dion; Michael D Slack; Lani F Wu; Steven J Altschuler; Oliver J Rando
Journal: Science Date: 2005-06-16 Impact factor: 47.728

5. Chromatin remodeling by ISW2 and SWI/SNF requires DNA translocation inside the nucleosome.

Authors: Martin Zofall; Jim Persinger; Stefan R Kassabov; Blaine Bartholomew
Journal: Nat Struct Mol Biol Date: 2006-03-05 Impact factor: 15.369

6. Chromatin potentiates transcription.

Authors: Shigeki Nagai; Ralph E Davis; Pierre Jean Mattei; Kyle Patrick Eagen; Roger D Kornberg
Journal: Proc Natl Acad Sci U S A Date: 2017-01-30 Impact factor: 11.205

7. Five SWI genes are required for expression of the HO gene in yeast.

Authors: M Stern; R Jensen; I Herskowitz
Journal: J Mol Biol Date: 1984-10-05 Impact factor: 5.469

8. Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin.

Authors: Alexandre A Boudreault; Dominique Cronier; William Selleck; Nicolas Lacoste; Rhea T Utley; Stéphane Allard; Julie Savard; William S Lane; Song Tan; Jacques Côté
Journal: Genes Dev Date: 2003-06-01 Impact factor: 11.361

9. Stimulation of transcription factor binding and histone displacement by nucleosome assembly protein 1 and nucleoplasmin requires disruption of the histone octamer.

Authors: P P Walter; T A Owen-Hughes; J Côté; J L Workman
Journal: Mol Cell Biol Date: 1995-11 Impact factor: 4.272

10. Asymmetric nucleosomes flank promoters in the budding yeast genome.

Authors: Srinivas Ramachandran; Gabriel E Zentner; Steven Henikoff
Journal: Genome Res Date: 2014-12-09 Impact factor: 9.043

5 in total

Review 1. Interplay among ATP-Dependent Chromatin Remodelers Determines Chromatin Organisation in Yeast.

Authors: Hemant K Prajapati; Josefina Ocampo; David J Clark
Journal: Biology (Basel) Date: 2020-07-25

2. Histone Deacetylase9 Represents the Epigenetic Promotion of M1 Macrophage Polarization and Inflammatory Response via TLR4 Regulation.

Authors: Xi Cao; Man Zhang; Hui Li; Kaiming Chen; Yong Wang; Jia Yang
Journal: Biomed Res Int Date: 2022-07-30 Impact factor: 3.246